What is the catalog number for Anti-Hu CD35 FITC?

The catalog number for Anti-Hu CD35 FITC is 1F-703-T100.

What sizes are available for Anti-Hu CD35 FITC?

Anti-Hu CD35 FITC is available in the following size(s): 100 Tests.

Is Anti-Hu CD35 FITC in stock?

Anti-Hu CD35 FITC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD35 FITC?

Anti-Hu CD35 FITC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD35 FITC?

Estimated delivery time for Anti-Hu CD35 FITC is approximately 10 business day(s), depending on your location.

Anti-Hu CD35 FITC

CD35 (complement receptor 1, CR1) is a monomeric multiple modular cell surface glycoprotein which serves as receptor for C3b and C4b, the most important components of the complement system leading to clearance of foreign macromolecules. It is expressed mainly on the surface of granulocytes, monocytes, erythrocytes, B cells and folicular dendritic cells. Besides its role in complement cascade, CD35 is involved in blocking BCR-induced proliferation and the differentiation of B cells to plasmablasts and their Ig production.

Product Specifications

Certification

RUO

Reactivity

Non-human primates, Human

Immunogen

Acute monocytic leukemia cells and normal blood monocytes

Target Antigen

CD35

Clone

E11

Applications

FC (QC tested)

Format

FITC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Hogg N, Ross GD, Jones DB, Slusarenko M, Walport MJ, Lachmann PJ: Identification of an anti-monocyte monoclonal antibody that is specific for membrane complement receptor type one (CR1) . Eur J Immunol. 1984 Mar;14 (3) :236-43., URL: http://www.ncbi.nlm.nih.gov/pubmed/6368248, *Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Martinez Casals A, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Mueller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ: Organ mapping antibody panels: a community resource for standardized multiplexed tissue imaging. Nat Methods 2023 Aug;20 (8) :1174-1178. doi: 10.1038/s41592-023-01846-7., URL: https://pubmed.ncbi.nlm.nih.gov/37468619/

Other References

*Nielsen CH, Pedersen ML, Marquart HV, Prodinger WM, Leslie RG: The role of complement receptors type 1 (CR1, CD35) and 2 (CR2, CD21) in promoting C3 fragment deposition and membrane attack complex formation on normal peripheral human B cells. Eur J Immunol. 2002 May;32 (5) :1359-67., URL: http://www.ncbi.nlm.nih.gov/pubmed/11981823, , *Kremlitzka M, Polgár A, Fülöp L, Kiss E, Poór G, Erdei A: Complement receptor type 1 (CR1, CD35) is a potent inhibitor of B-cell functions in rheumatoid arthritis patients. Int Immunol. 2012 Sep 7. [Epub ahead of print], URL: https://pubmed.ncbi.nlm.nih.gov/22962438/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody E11 recognizes an extracellular epitope of CD35 (CR1), a type I transmembrane glycoprotein expressed on granulocytes, monocytes, B cells, folicular dendritic cells, erythrocytes, NK and T cell subsets, as well as e.g. on glomerulal podocytes.