What is the catalog number for Anti-Hu CD135 FITC?

The catalog number for Anti-Hu CD135 FITC is 1F-587-T100.

What sizes are available for Anti-Hu CD135 FITC?

Anti-Hu CD135 FITC is available in the following size(s): 100 Tests.

Is Anti-Hu CD135 FITC in stock?

Anti-Hu CD135 FITC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD135 FITC?

Anti-Hu CD135 FITC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD135 FITC?

Estimated delivery time for Anti-Hu CD135 FITC is approximately 10 business day(s), depending on your location.

Anti-Hu CD135 FITC

CD135 / FLT3, also known as FLK2 or STK-1 is a receptor tyrosine kinase that plays important roles in hematopoiesis. After binding of Flt3 ligand (FL), CD135 homodimerizes and stimulates proliferation, differentiation and protects the cell from apoptosis. The loss of CD90 and gain of CD135 expression marks the loss of self-renewal in hematopoietic stem cell population. Detectable CD135 expression appears first at low levels on the surface of primitive multilineage progenitor cells and disappears during defined stages of B-cell development, but is upregulated and maintained during maturation of monocytes. CD135 is also expressed on thymocytes, dendritic cell progenitors and on mature dendritic cells, as well as on various malignant hematopoietic cells.

Product Specifications

Certification

RUO

Negative Species

Mouse

Reactivity

Human

Immunogen

BV-173 leukemic cell line

Target Antigen

CD135

Clone

BV10A4

Applications

FC (QC tested)

Format

FITC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Leukocyte Typing VI., Kishimoto T. et al. (Eds.), Garland Publishing Inc. (1997) ., URL: , *Haylock DN, Horsfall MJ, Dowse TL, Ramshaw HS, Niutta S, Protopsaltis S, Peng L, Burrell C, Rappold I, Buhring HJ, Simmons PJ: Increased recruitment of hematopoietic progenitor cells underlies the ex vivo expansion potential of FLT3 ligand. Blood. 1997 Sep 15;90 (6) :2260-72., URL: https://www.ncbi.nlm.nih.gov/pubmed/9310477?ordina, *Masuda H, Anwar SS, Bühring HJ, Rao JR, Gargett CE: A novel marker of human endometrial mesenchymal stem-like cells. Cell Transplant. 2012;21 (10) :2201-14., URL: https://www.ncbi.nlm.nih.gov/pubmed/22469435

Other References

*Kuchenbauer F, Kern W, Schoch C, Kohlmann A, Hiddemann W, Haferlach T, Schnittger S: Detailed analysis of FLT3 expression levels in acute myeloid leukemia. Haematologica. 2005 Dec;90 (12) :1617-25., URL: https://www.ncbi.nlm.nih.gov/pubmed/16330434?ordin, *Whartenby KA, Calabresi PA, McCadden E, Nguyen B, Kardian D, Wang T, Mosse C, Pardoll DM, Small D: Inhibition of FLT3 signaling targets DCs to ameliorate autoimmune disease. Proc Natl Acad Sci U S A. 2005 Nov 15;102 (46) :16741-6., URL: https://www.ncbi.nlm.nih.gov/pubmed/16272221?ordin, *Christensen JL, Weissman IL: Flk-2 is a marker in hematopoietic stem cell differentiation: a simple method to isolate long-term stem cells. Proc Natl Acad Sci U S A. 2001 Dec 4;98 (25) :14541-6., URL: https://www.ncbi.nlm.nih.gov/pubmed/11724967?ordin, *Rappold I, Ziegler BL, Köhler I, Marchetto S, Rosnet O, Birnbaum D, Simmons PJ, Zannettino AC, Hill B, Neu S, Knapp W, Alitalo R, Alitalo K, Ullrich A, Kanz L, Bühring HJ: Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase. Blood. 1997 Jul 1;90 (1) :111-25., URL: https://www.ncbi.nlm.nih.gov/pubmed/9207445?ordina

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody BV10A4 (BV10) reacts with an extracellular epitope of CD135 (FLT3, FLK2, STK-1), a 130-160 kDa type I transmembrane receptor tyrosine kinase that is involved in early steps of hematopoiesis.