Anti-Hu CD53 FITC
CD53 is a tetraspanin family transmembrane glycoprotein expressed in the lymphoid-myeloid lineage. This molecule has been reported to form complexes with other leukocyte surface proteins such as CD2, CD19, CD21, MHC II, VLA-4 or tetraspanins CD37, CD81 and CD82, thus probably modulating various signaling processes. CD53 is involved in radioresistancy of tumour cells and its triggering has anti-apoptotic effect. In thymus, CD53 is up-regulated in response to positive selection signals during T cell development, and is strongly expressed upon macrophage exposure to bacterial lipopolysaccharide, whereas stimulation of neutrophils results in down-regulation of CD53 expression.
Product Specifications
Certification
RUO
Immunogen
Leukocytes of pacient suffering from a LGL-type leukemia.
Target Antigen
CD53
Clone
MEM-53
Applications
FC (QC tested)
Format
FITC
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Other References
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
Applications Notes
6
Species
Human
CAS Number
9007-83-4
Isotype
Mouse IgG1
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items