Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD45RA FITC

CD45RA is a high molecular weight isoform of a receptor-type protein tyrosine phosphatase, CD45 glycoprotein. CD45 is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45 isoforms differ in their extracellular domains, whereas they share identical transmembrane and cytoplasmic domains. These isoforms differ in their ability to translocate into the glycosphingolipid-enriched membrane domains and their expression depends on cell type and physiological state of the cell. CD45RA is expressed e.g. on naï ve T cells and normal plasma cells.

Product Specifications

Certification

RUO

Immunogen

Human thymocytes and T lymphocytes.

Target Antigen

CD45RA

Clone

MEM-56

Applications

FC (QC tested)

Format

FITC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Bazil V, Stefanova I, Hilgert I, Kristofova H, Vanek S, Bukovsky A, Horejsi V: Monoclonal antibodies against human leucocyte antigens. III. Antibodies against CD45R, CD6, CD44 and two newly described broadly expressed glycoproteins MEM-53 and MEM-102. Folia Biol (Praha) . 1989;35 (5) :289-97. , URL: https://www.ncbi.nlm.nih.gov/pubmed/2534480?dopt=A, *Leukocyte Typing IV., Knapp W. et al. (Eds.), Oxford University Press (1989) ., URL:

Other References

*Li FJ, Tsuyama N, Ishikawa H, Obata M, Abroun S, Liu S, Otsuyama K, Zheng X, Ma Z, Maki Y, Kawano MM: A rapid translocation of CD45RO but not CD45RA to lipid rafts in IL-6-induced proliferation in myeloma. Blood. 2005 Apr 15;105 (8) :3295-302. , URL: http://www.ncbi.nlm.nih.gov/pubmed/15626731?ordina, *Cosenza-Nashat MA, Kim MO, Zhao ML, Suh HS, Lee SC: CD45 isoform expression in microglia and inflammatory cells in HIV-1 encephalitis. Brain Pathol. 2006 Oct;16 (4) :256-65., URL: http://www.ncbi.nlm.nih.gov/pubmed/17107594?ordina, *Dawes R, Petrova S, Liu Z, Wraith D, Beverley PC, Tchilian EZ. Combinations of CD45 isoforms are crucial for immune function and disease. J Immunol. 2006 Mar 15;176 (6) :3417-25., URL: http://www.ncbi.nlm.nih.gov/pubmed/16517710?ordina, *Bijian K, Zhang L, Shen SH: Collagen-mediated survival signaling is modulated by CD45 in Jurkat T cells. Mol Immunol. 2007 Jul;44 (15) :3682-90., URL: http://www.ncbi.nlm.nih.gov/pubmed/17524482?ordina, *Desharnais P, Dupéré-Minier G, Hamelin C, Devine P, Bernier J: Involvement of CD45 in DNA fragmentation in apoptosis induced by mitochondrial perturbing agents. Apoptosis. 2007 Dec 19 , URL: http://www.ncbi.nlm.nih.gov/pubmed/18157742?ordina

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody MEM-56 reacts with an extracellular epitope of CD45RA, a 205-220 kDa single chain type I glycoprotein, variant of CD45 (CD45RA isoform) . CD45RA is expressed on most of B lymphocytes, resting and native T lymphocytes, medullar thymocytes and monocytes.

Applications Notes

6

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG2b

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Inhibitor mmu-miR-6539 AAV miRNA Vector
Amm3132200 500 ng

Inhibitor mmu-miR-6539 AAV miRNA Vector

Ask
View Details
Utp14a Mouse shRNA Lentiviral Particle (Locus ID 72554)
TL504747V 500 µL Each

Utp14a Mouse shRNA Lentiviral Particle (Locus ID 72554)

Ask
View Details
EML2 Protein Vector (Mouse) (pPM-C-HA)
19261025 500 ng

EML2 Protein Vector (Mouse) (pPM-C-HA)

Ask
View Details
ATMIN siRNA (Mouse)
MBS8201541-01 15 nmol

ATMIN siRNA (Mouse)

Ask
View Details
ATMIN siRNA (Mouse)
MBS8201541-02 30 nmol

ATMIN siRNA (Mouse)

Ask
View Details
ATMIN siRNA (Mouse)
MBS8201541-03 5x 30 nmol

ATMIN siRNA (Mouse)

Ask
View Details