Liensinine (Diperchlorate)

Liensinine Diperchlorate is a major isoquinoline alkaloid, extracted from the seed embryo of Nelumbo nucifera Gaertn. Liensinine Diperchlorate inhibits late-stage autophagy/mitophagy through blocking autophagosome-lysosome fusion. Liensinine Diperchlorate has a wide range of biological activities, including anti-arrhythmias, anti-hypertension, anti-pulmonary fibrosis, relaxation on vascular smooth muscle, etc[1].

Product Specifications

CAS Number

[5088-90-4]

UNSPSC

12352005

Target

Autophagy; Mitophagy

Type

Natural Products

Related Pathways

Autophagy

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/liensinine-diperchlor-ate.html

Purity

99.96

Solubility

DMSO : 62.5 mg/mL (ultrasonic)

Smiles

O=Cl(=O)(O)=O.CN1[C@@H](C2=CC(OC3=CC(C[C@@H]4C5=CC(OC)=C(OC)C=C5CCN4C)=CC=C3O)=C(OC)C=C2CC1)CC6=CC=C(O)C=C6.O=Cl(=O)(O)=O

Molecular Formula

C37H44Cl2N2O14

Molecular Weight

811.66

References & Citations

[1]Zhou J, et al. A novel autophagy/mitophagy inhibitor liensinine sensitizes breast cancer cells to chemotherapy through DNM1L-mediated mitochondrial fission. Autophagy. 2015;11 (8) :1259-79.