What is the catalog number for Anti-Hu CD49d FITC?

The catalog number for Anti-Hu CD49d FITC is 1F-171-T100.

What sizes are available for Anti-Hu CD49d FITC?

Anti-Hu CD49d FITC is available in the following size(s): 100 Tests.

Is Anti-Hu CD49d FITC in stock?

Anti-Hu CD49d FITC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD49d FITC?

Anti-Hu CD49d FITC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD49d FITC?

Estimated delivery time for Anti-Hu CD49d FITC is approximately 10 business day(s), depending on your location.

Anti-Hu CD49d FITC

CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.

Product Specifications

Certification

RUO

Reactivity

Sheep, Cat, Horse, Dog, Cow, Non-human primates, Human

Target Antigen

CD49d

Clone

9F10

Applications

FC (QC tested)

Format

FITC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Stenner MP, Waschbisch A, Buck D, Doerck S, Einsele H, Toyka KV, Wiendl H: Effects of natalizumab treatment on Foxp3+ T regulatory cells. PLoS One. 2008 Oct 6;3 (10) :e3319. , URL: http://www.ncbi.nlm.nih.gov/pubmed/18836525, *Chigaev A, Waller A, Amit O, Halip L, Bologa CG, Sklar LA: Real-time analysis of conformation-sensitive antibody binding provides new insights into integrin conformational regulation. J Biol Chem. 2009 May 22;284 (21) :14337-46, URL: http://www.ncbi.nlm.nih.gov/pubmed/19251697 , *Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross CC, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, Wiendl H: VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. J Exp Med. 2014 Aug 25;211 (9) :1833-46., URL: https://pubmed.ncbi.nlm.nih.gov/25135296/, *Yoon SO, Lee IY, Zhang X, Zapata MC, Choi YS: CD9 may contribute to the survival of human germinal center B cells by facilitating the interaction with follicular dendritic cells. FEBS Open Bio. 2014 Apr 13;4:370-6. , URL: http://www.ncbi.nlm.nih.gov/pubmed/24918051 , *Zhang XF, Feng MF: Adherence of human monocytes and NK cells to human TNF-alpha-stimulated porcine endothelial cells. Immunol Cell Biol. 2000 Dec;78 (6) :633-40., URL: http://www.ncbi.nlm.nih.gov/pubmed/11114974 , *Soler D, Chapman T, Yang LL, Wyant T, Egan R, Fedyk ER: The binding specificity and selective antagonism of vedolizumab, an anti-alpha4beta7 integrin therapeutic antibody in development for inflammatory bowel diseases. J Pharmacol Exp Ther. 2009 Sep;330 (3) :864-75., URL: https://pubmed.ncbi.nlm.nih.gov/19509315/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 9F10 recognizes an extracellular epitope of CD49d (alpha 4 integrin), a 145-180 kDa type I transmembrane glycoprotein expressed on B and T cells, monocytes, eosinophils, basophils, NK cells, and dendritic cells, but not platelets.