What is the catalog number for Anti-Hu CD22 Biotin?

The catalog number for Anti-Hu CD22 Biotin is 1B-265-C100.

What sizes are available for Anti-Hu CD22 Biotin?

Anti-Hu CD22 Biotin is available in the following size(s): 0.1 mg.

Is Anti-Hu CD22 Biotin in stock?

Anti-Hu CD22 Biotin is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD22 Biotin?

Anti-Hu CD22 Biotin is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD22 Biotin?

Estimated delivery time for Anti-Hu CD22 Biotin is approximately 10 business day(s), depending on your location.

Anti-Hu CD22 Biotin

CD22, also known as Siglec-2 (sialic acid-binding immunoglobulin-like lectin-2) is a transmembrane glycoprotein binding alpha2,6-linked sialic acid-bearing ligands. Intracellular domain of CD22 recruits protein tyrosine phosphatase SHP-1 through the immunoreceptor tyrosine-based inhibitory motifs (ITIMs), thus setting a treshold for B cell receptor-mediated activation. CD22 also regulates B-cell response by involvement in controlling the CD19/CD21-Src-family protein tyrosine kinase amplification pathway and CD40 signaling. CD22 exhibits hallmarks of clathrin-mediated endocytic pathway.

Product Specifications

Certification

RUO

Reactivity

Human, Non-human primates

Immunogen

Raji Burkitt's lymphoma cell line

Target Antigen

CD22

Clone

MEM-01

Applications

FC (QC tested), IP, WB

Concentration

1 mg/mL

Format

Biotin

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Walker JA, Smith KG: CD22: an inhibitory enigma. Immunology. 2007 Dec 7, URL: https://www.ncbi.nlm.nih.gov/pubmed/18067554?ordin, *Tateno H, Li H, Schur MJ, Bovin N, Crocker PR, Wakarchuk WW, Paulson JC: Distinct endocytic mechanisms of CD22 (Siglec-2) and Siglec-F reflect roles in cell signaling and innate immunity. Mol Cell Biol. 2007 Aug;27 (16) :5699-710., URL: https://www.ncbi.nlm.nih.gov/pubmed/17562860?ordin, *Tedder TF, Poe JC, Haas KM: CD22: A Multifunctional Receptor That Regulates B Lymphocyte Survival and Signal Transduction. Adv Immunol. 2005;88:1-50. , URL: https://www.ncbi.nlm.nih.gov/pubmed/16227086?ordin

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The antibody MEM-01 reacts with an extracellular epitope of CD22 (BL-CAM), a 130 kDa type I transmembrane glycoprotein (immunoglobulin superfamily) expressed in the cytoplasm of pro-B and pre-B lymphocytes, and on the surface of mature and activated B lymphocytes; it is lost on plasma cells, peripheral blood T lymphocytes, granulocytes and monocytes. The antibody MEM-01 cross-blocks the antibody OTH228 that recognizes uniquely epitope "E"; it does not cross-block antibodies RFB-4, CLB22/1 and CLB-BLy1.