PAMP-12 (Human)

<strong>PAMP-12 (Human)</strong> <strong>Catalog number:</strong> MDP0710 <strong>CAS Number: </strong>N/A <strong>Sequence: </strong>Phe-Arg-Lys-Lys-Trp-Asn-Lys-Trp-Ala-Leu-Ser-Arg-NH2 <strong>Amount:</strong> 500 ug <strong>Molecular Weight:</strong> 1618.8 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Chen E, Chuang LS, Giri M, Villaverde N, Hsu NY, Sabic K, Joshowitz S, Gettler K, Nayar S, Chai Z, Alter IL, Chasteau CC, Korie UM, Dzedzik S, Thin TH, Jain A, Moscati A, Bongers G, Duerr RH, Silverberg MS, Brant SR, Rioux JD, Peter I, Schumm LP, Haritunians T, McGovern DP, Itan Y, Cho JH. Inflamed Ulcerative Colitis Regions Associated With MRGPRX2-Mediated Mast Cell Degranulation and Cell Activation Modules, Defining a New Therapeutic Target Gastroenterology. 2021 Apr;160(5):1709-1724. 2: Bawazir M, Amponnawarat A, Hui Y, Oskeritzian CA, Ali H. Inhibition of MRGPRX2 but not FcεRI or MrgprB2-mediated mast cell degranulation by a small molecule inverse receptor agonist Front Immunol. 2022 Oct 6;13:1033794. 3: Belloni AS, Rossi GP, Andreis PG, Aragona F, Champion HC, Kadowitz PJ, Murphy WA, Coy DH, Nussdorfer GG. Proadrenomedullin N-terminal 20 peptide (PAMP), acting through PAMP(12-20)-sensitive receptors, inhibits Ca2+-dependent, agonist-stimulated secretion of human adrenal glands Hypertension. 1999 May;33(5):1185-9. 4: Fry RC, Champion HC, Lawrence TC, Murphy WA, Coy DH, Kadowitz PJ. Proadrenomedullin NH2-terminal peptide (PAMP)(12-20) has vasodepressor activity in the rat and cat Life Sci. 1997;60(10):PL161-7. 5: Lu L, Parmar MB, Kulka M, Kwan P, Unsworth LD. Self-Assembling Peptide Nanoscaffold That Activates Human Mast Cells ACS Appl Mater Interfaces. 2018 Feb 21;10(7):6107-6117. 6: Nussdorfer GG. Proadrenomedullin-derived peptides in the paracrine control of the hypothalamo-pituitary-adrenal axis Int Rev Cytol. 2001;206:249-84. 7: Kamohara M, Matsuo A, Takasaki J, Kohda M, Matsumoto M, Matsumoto S, Soga T, Hiyama H, Kobori M, Katou M. Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides Biochem Biophys Res Commun. 2005 May 20;330(4):1146-52. 8: Kuwasako K, Kitamura K, Kangawa K, Ishiyama Y, Kato J, Eto T. Increased plasma proadrenomedullin N-terminal 20 peptide in patients with essential hypertension Ann Clin Biochem. 1999 Sep;36 ( Pt 5):622-8. 9: Raj S, Lu L, Unsworth LD. Screening Peptides that Activate MRGPRX2 using Engineered HEK Cells J Vis Exp. 2021 Nov 6;(177). <a href="https://pubmed.ncbi.nlm.nih.gov/36329102">10: Yoshida K, Tanihara S, Miyashita Y, Obayashi K, Ito MA, Yamamoto K, Imai T, Matsuoka I. P2X4 receptor stimulation enhances MrgprB2-mediated mast cell activation and pseudoallergic reactions in mice Sci Rep. 2022 Nov 3;12(1):18613. </a> <br><strong>Products Related to PAMP-12 (Human) can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>