Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD140a APC

CD140a / PDGF-RA (platelet-derived growth factor receptor alpha) is a cell surface receptor for members of platelet-derived growth factor family, whose intracellular part contains a tyrosine kinase domain. CD140a forms homodimers, or heterodimerizes with CD140b / PDGF-RB. Whereas CD140b induces in different cell types their proliferation and migration, the role of CD140a is more controversial, with pro-proliferative or anti-proliferative effects. CD140a has early developmental functions, mediates mesodermal cell migration, and later acts in signaling associated in epithelial-mesenchymal interactions.

Product Specifications

Certification

RUO

Immunogen

CD140a-transfected NIH 3T3 cells

Target Antigen

CD140a

Clone

16A1

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Ricono JM, Wagner B, Gorin Y, Arar M, Kazlauskas A, Choudhury GG, Abboud HE: PDGF receptor-{beta} modulates metanephric mesenchyme chemotaxis induced by PDGF AA. Am J Physiol Renal Physiol. 2009 Feb;296 (2) :F406-17. (IF), URL: https://pubmed.ncbi.nlm.nih.gov/19019919/

Other References

*Faraone D, Aguzzi MS, Toietta G, Facchiano AM, Facchiano F, Magenta A, Martelli F, Truffa S, Cesareo E, Ribatti D, Capogrossi MC, Facchiano A: Platelet-derived growth factor-receptor alpha strongly inhibits melanoma growth in vitro and in vivo. Neoplasia. 2009 Aug;11 (8) :732-42., URL: https://www.ncbi.nlm.nih.gov/pubmed/19649203?itool, *Schmahl J, Rizzolo K, Soriano P: The PDGF signaling pathway controls multiple steroid-producing lineages. Genes Dev. 2008 Dec 1;22 (23) :3255-67., URL: https://www.ncbi.nlm.nih.gov/pubmed/19056881?itool, *French WJ, Creemers EE, Tallquist MD: Platelet-derived growth factor receptors direct vascular development independent of vascular smooth muscle cell function. Mol Cell Biol. 2008 Sep;28 (18) :5646-57., URL: https://www.ncbi.nlm.nih.gov/pubmed/18606782?itool, *Andrae J, Gallini R, Betsholtz C: Role of platelet-derived growth factors in physiology and medicine. Genes Dev. 2008 May 15;22 (10) :1276-312., URL: https://www.ncbi.nlm.nih.gov/pubmed/18483217?itool

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 16A1 recognizes an extracellular epitope of CD140a / PDGF-RA, the 170 kDa alpha chain of platelet-derived growth factor receptor, which is widely expressed on a variety of mesenchymal-derived cells and plays pro-proliferative or anti-proliferative roles in various tumours.

Applications Notes

6

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG1 kappa

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

PRA20 rabbit pAb
ES13976-01 50 µL

PRA20 rabbit pAb

Ask
View Details
PRA20 rabbit pAb
ES13976-02 100 µL

PRA20 rabbit pAb

Ask
View Details
T2R38 Antibody FITC Conjugated
C07604F 100 µL

T2R38 Antibody FITC Conjugated

Ask
View Details
S1PR2 (NM_004230) Human Recombinant Protein
E45H37375M5 20 ug

S1PR2 (NM_004230) Human Recombinant Protein

Ask
View Details
NativeExtract™ Human GPR15 Membrane Protein (Full length, Super Nanodisc)
S01YF-1023-KX220 10 μg

NativeExtract™ Human GPR15 Membrane Protein (Full length, Super Nanodisc)

Ask
View Details
2,5-Diazaspiro[3.5]nonane, N2-BOC protected
OR312203-01 250 mg

2,5-Diazaspiro[3.5]nonane, N2-BOC protected

Ask
View Details