What is the catalog number for Anti-Hu CD52 APC?

The catalog number for Anti-Hu CD52 APC is 1A-368-T100.

What sizes are available for Anti-Hu CD52 APC?

Anti-Hu CD52 APC is available in the following size(s): 100 Tests.

Is Anti-Hu CD52 APC in stock?

Anti-Hu CD52 APC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD52 APC?

Anti-Hu CD52 APC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD52 APC?

Estimated delivery time for Anti-Hu CD52 APC is approximately 10 business day(s), depending on your location.

Anti-Hu CD52 APC

CD52 (CAMPATH-1, HE5) is a highly glycosylated GPI-anchored 21-28 kDa glycopeptide which is present at high levels on lymphocytes, macrophages, epithelial cells of male reproductive tract and mature sperm. Its 12-amino acid beckbone carries a complex N-linked carbohydrate moiety, which differs between sperm and leukocyte CD52, as well as the GPI anchor does. CD52 can be acquired by sperm cells from seminal plasma, where it is released by epithelial cells. Although CD52 is not an essential T-cell costimulator, its triggering results in activation of normal human T cells. CD52 is a very good target for antibody/complement-mediated cell lysis.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human tonsil

Target Antigen

CD52

Clone

HI186

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Schröter S, Derr P, Conradt HS, Nimtz M, Hale G, Kirchhoff C: Male-specific modification of human CD52. J Biol Chem. 1999 Oct 15;274 (42) :29862-73., URL: https://www.ncbi.nlm.nih.gov/pubmed/10514467?ordin, *Treumann A, Lifely MR, Schneider P, Ferguson MA: Primary structure of CD52. J Biol Chem. 1995 Mar 17;270 (11) :6088-99. , URL: https://www.ncbi.nlm.nih.gov/pubmed/7890742?ordina, *Rowan WC, Hale G, Tite JP, Brett SJ: Cross-linking of the CAMPATH-1 antigen (CD52) triggers activation of normal human T lymphocytes. Int Immunol. 1995 Jan;7 (1) :69-77., URL: https://www.ncbi.nlm.nih.gov/pubmed/7718516?ordina, *Koyama K, Ito K, Hasegawa A: Role of male reproductive tract CD52 (mrt-CD52) in reproduction. Soc Reprod Fertil Suppl. 2007;63:103-10., URL: https://www.ncbi.nlm.nih.gov/pubmed/17566265?ordin, *Domagała A, Kurpisz M: CD52 antigen--a review. Med Sci Monit. 2001 Mar-Apr;7 (2) :325-31., URL: https://www.ncbi.nlm.nih.gov/pubmed/11257744?ordin

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The antibody HI186 reacts with CD52 (CAMPATH-1), a 21-28 kDa extracellular glycoprotein containing a large N-linked carbohydrate moiety; mature CD52 molecule is actually much smaller (approx. 8-9 kDa) . CD52 is expressed at high levels on lymphocytes, monocytes/macrophages and in male reproductive tract.