Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu CD122 APC

CD122 (IL-2/IL-15R beta) constitutes together with CD132 (common gamma chain) and with CD25 (IL-2/IL15R alpha) the intermediate (CD122+CD132) and the high affinity (CD122+CD132+CD25) IL-2 and IL-15 receptor complex. CD122 is expressed on NK cells and lymphocytes, but at low level, unless the cell is activated. The cytoplasmic part of CD122 binds to Src-family and Jak-family kinases. The biological effect of CD122 ligation depends on whether IL-2 or IL-15 is bound to the receptor complex.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

TL-Mor cell line

Target Antigen

CD122

Clone

TU27

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Elkins J, Sheridan J, Amaravadi L, Riester K, Selmaj K, Bielekova B, Parr E, Giovannoni G: CD56 (bright) natural killer cells and response to daclizumab HYP in relapsing-remitting MS. Neurol Neuroimmunol Neuroinflamm. 2015 Jan 22;2 (2) :e65., URL: http://www.ncbi.nlm.nih.gov/pubmed/25635261 , *Gallart T, de la Fuente MA, Barceló JJ, Alberola-Ila J, Lozano F: Desialylation of T lymphocytes overcomes the monocyte dependency of pokeweed mitogen-induced T-cell activation. Immunology 1997 Jan;90 (1) :57-65., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=desialylation+of+t+lymphocytes+overcomes+the+monocyte+dependency+of+pokeweed , *Sharkey AM, Xiong S, Kennedy PR, Gardner L, Farrell LE, Chazara O, Ivarsson MA, Hiby SE, Colucci F, Moffett A: Tissue-Specific Education of Decidual NK Cells. J Immunol. 2015 Oct 1;195 (7) :3026-32., URL: http://www.ncbi.nlm.nih.gov/pubmed/26320253 , *Ozawa A, Tada H, Tamai R, Uehara A, Watanabe K, Yamaguchi T, Shimauchi H, Takada H, Sugawara S: Expression of IL-2 receptor beta and gamma chains by human gingival fibroblasts and up-regulation of adhesion to neutrophils in response to IL-2. J Leukoc Biol. 2003 Sep;74 (3) :352-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/12949238 , *Sahraoui Y, Perraki M, Theodoropoulou M, Allouche M, Tsapis A, Ammar A, Clemenceau C, Bokogiorgou S, Yacci T, Katrinakis G, Jasmin C, Georgoulias V: Autocrine IL-2-dependent growth of a newly established CD3+, CD16-, CD56+, CD57+, J (H) -, TCRbeta-, TCRgamma- leukemia cell line (NOI-90) . Leukemia. 1997 Feb;11 (2) :245-52., URL: http://www.ncbi.nlm.nih.gov/pubmed/9009088 , *Huss DJ, Mehta DS, Sharma A, You X, Riester KA, Sheridan JP, Amaravadi LS, Elkins JS, Fontenot JD: In vivo maintenance of human regulatory T cells during CD25 blockade. J Immunol. 2015 Jan 1;194 (1) :84-92., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=huss+dj+mehta+ds+sharma+a

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody TU27 recognizes an extracellular epitope of CD122 (IL-2R beta), a 70-75 kDa type I transmembrane glycoprotein constitutively expressed by NK cells and a T cell subset, and upregulated upon activation.

Applications Notes

6

Isotype

Mouse IgG1 kappa

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

IL26 Antibody Blocking peptide
orb1456970 500 µg

IL26 Antibody Blocking peptide

Sign In for Pricing
View Details
CDH3 Recombinant Protein (Rat)
RP194237 100 µg

CDH3 Recombinant Protein (Rat)

Sign In for Pricing
View Details
Serum for HCC38 Cell Culture
C6290F-500ml 500 mL

Serum for HCC38 Cell Culture

Sign In for Pricing
View Details
Recombinant Human TTC8, GST-tagged
TTC8-3477H 25 µg

Recombinant Human TTC8, GST-tagged

Sign In for Pricing
View Details
Lentiviral mouse Rph3a shRNA (UAS) - Lentiviral mouse Rph3a shRNA (UAS, iRFP) plasmid
GTR15212560 1 Vial

Lentiviral mouse Rph3a shRNA (UAS) - Lentiviral mouse Rph3a shRNA (UAS, iRFP) plasmid

Sign In for Pricing
View Details
PmirGLO-IGFBP5 3’-UTR (mutant)
PPL00867-2c 1 Each

PmirGLO-IGFBP5 3’-UTR (mutant)

Sign In for Pricing
View Details