Tyrosine Kinase Receptor A (Human)

<strong>Tyrosine kinase receptor A</strong>_x000D_ <strong>Catalog number:</strong> B2010372_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Human Tyrosine kinase receptor A expressed in HEK 293. This protein acts as a high affinity catalytic receptor for neurotrophin and nerve growth factor (NGF). It also mediates the multiple effects of NGF, which include neuronal differentiation and avoidance of programmed cell death._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuTrkA; NTRK1; MTC; TRK_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Du Z, Lovly CM. Mechanisms of receptor tyrosine_kinase activation in cancer._x000D_ Mol Cancer. 2018 Feb 19;17(1):58._x000D_ _x000D_ 2: Trenker R, Jura N. Receptor_tyrosine kinase activation: From the ligand_x000D_ perspective. Curr Opin Cell Biol. 2020 Apr;63:174-185._x000D_ _x000D_ 3: Hallberg B, Palmer RH. Mechanistic insight into ALK receptor tyrosine kinase_x000D_ in human cancer biology. Nat Rev Cancer. 2013 Oct;13(10):685-700._x000D_ 24060861._x000D_ _x000D_ 4: Hallberg B, Palmer RH. The role of the ALK receptor in cancer biology. Ann_x000D_ Oncol. 2016 Sep;27 Suppl 3:iii4-iii15._x000D_ _x000D_ 5: Linger RM, Keating AK, Earp HS, Graham DK. TAM receptor tyrosine_kinases:_x000D_ biologic functions, signaling, and potential therapeutic targeting in human_x000D_ cancer. Adv Cancer Res. 2008;100:35-83._x000D_ _x000D_ 6: Nakada M, Kita D, Teng L, Pyko IV, Watanabe T, Hayashi Y, Hamada JI. Receptor_x000D_ Tyrosine Kinases: Principles and Functions in Glioma Invasion. Adv Exp Med Biol._x000D_ 2020;1202:151-178._x000D_ _x000D_ 7: Sun ZG, Liu JH, Zhang JM, Qian Y. Research Progress of Axl Inhibitors. Curr_x000D_ Top Med Chem. 2019;19(15):1338-1349._x000D_ _x000D_ 8: Biarc J, Chalkley RJ, Burlingame AL, Bradshaw RA. Receptor tyrosine_kinase_x000D_ signaling--a proteomic perspective. Adv Enzyme Regul. 2011;51(1):293-305._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/19756300/">_x000D_ 9: Dengjel J, Kratchmarova I, Blagoev B. Receptor tyrosine kinase signaling: a_x000D_ view from quantitative proteomics. Mol Biosyst. 2009 Oct;5(10):1112-21. </a>_x000D_ _x000D_ <strong>Products Related to Human Tyrosine kinase receptor A </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>