Anti-Hu CD1a APC

*Kader M, Smith AP, Guiducci C, Wonderlich ER, Normolle D, Watkins SC, Barrat FJ, Barratt-Boyes SM: Blocking TLR7- and TLR9-mediated IFN-α production by plasmacytoid dendritic cells does not diminish immune activation in early SIV infection. PLoS Pathog. 2013;9 (7) :e1003530., URL: https://pubmed.ncbi.nlm.nih.gov/23935491/, *Awasthi S, Wolf R, White G: Ontogeny and phagocytic function of baboon lung dendritic cells. Immunol Cell Biol. 2009 Jul;87 (5) :419-27., URL: http://www.ncbi.nlm.nih.gov/pubmed/19223853 , *Tenca C, Merlo A, Zarcone D, Saverino D, Bruno S, De Santanna A, Ramarli D, Fabbi M, Pesce C, Deaglio S, Ciccone E, Malavasi F, Grossi CE: Death of T cell precursors in the human thymus: a role for CD38. Int Immunol. 2003 Sep;15 (9) :1105-16., URL: http://www.ncbi.nlm.nih.gov/pubmed/12917263 , *Brown KN, Trichel A, Barratt-Boyes SM: Parallel loss of myeloid and plasmacytoid dendritic cells from blood and lymphoid tissue in simian AIDS. J Immunol. 2007 Jun 1;178 (11) :6958-67., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=brown+kn+trichel+a , *Zimmer MI, Larregina AT, Castillo CM, Capuano S 3rd, Falo LD Jr, Murphey-Corb M, Reinhart TA, Barratt-Boyes SM: Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood. 2002 Apr 15;99 (8) :2859-68., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=zimmer+mi+larregina+at+castillo+cm , *Wood GS, Burns BF, Dorfman RF, Warnke RA: The immunohistology of non-T cells in the acquired immunodeficiency syndrome. Am J Pathol. 1985 Sep;120 (3) :371-9., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=am+j+pathol+120+371

The mouse monoclonal antibody SK9 recognizes an extracellular epitope of CD1a (T6), a 49 kDa polypeptide associated with beta2-microglobulin expressed on cortical thymocytes (strongly), Langerhans cells, dendritic cells and some T cell leukemias and lymphomas.