What is the catalog number for Anti-Hu CD134 APC?

The catalog number for Anti-Hu CD134 APC is 1A-152-T100.

What sizes are available for Anti-Hu CD134 APC?

Anti-Hu CD134 APC is available in the following size(s): 100 Tests.

Is Anti-Hu CD134 APC in stock?

Anti-Hu CD134 APC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD134 APC?

Anti-Hu CD134 APC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD134 APC?

Estimated delivery time for Anti-Hu CD134 APC is approximately 10 business day(s), depending on your location.

Anti-Hu CD134 APC

CD134 (TNFRSF4, also known as OX40) is a type I transmembrane glycoprotein of TNF/NGF receptor family expressed on activated T cells, fibroblasts, and hematopoietic precursors. Binding to its ligand (OX40L, TNFSF4) on antigen presenting cells gives to the T cell costimulatory signal, and this interaction results also in B cell proliferation and influences T cell memory pool. CD134 is upregulated at sites of inflammation, especially in case of multiple sclerosis and psoriatic lesions.

Product Specifications

Certification

RUO

Reactivity

Non-human primates, Human

Immunogen

HTLV 1-transformed HUT-102 cells

Target Antigen

CD134

Clone

Ber-ACT35

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Endl J, Rosinger S, Schwarz B, Friedrich SO, Rothe G, Karges W, Schlosser M, Eiermann T, Schendel DJ, Boehm BO: Coexpression of CD25 and OX40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes. Diabetes. 2006 Jan;55 (1) :50-60., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=endl+j+rosinger+s+schwarz+b , *Aten J, Roos A, Claessen N, Schilder-Tol EJ, Ten Berge IJ, Weening JJ: Strong and selective glomerular localization of CD134 ligand and TNF receptor-1 in proliferative lupus nephritis. J Am Soc Nephrol. 2000 Aug;11 (8) :1426-38., URL: http://www.ncbi.nlm.nih.gov/pubmed/10906156 , *Jones D, Fletcher CD, Pulford K, Shahsafaei A, Dorfman DM: The T-cell activation markers CD30 and OX40/CD134 are expressed in nonoverlapping subsets of peripheral T-cell lymphoma. Blood. 1999 May 15;93 (10) :3487-93., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=jones+d+pulford+k , *Li M, Zhang Y: The effect of anti-human CD134 monoclonal antibody on phytohemagglutinin-induced mRNA expression of perforin in peripheral blood mononuclear cells. Cell Mol Immunol. 2005 Dec;2 (6) :467-71., URL: http://www.ncbi.nlm.nih.gov/pubmed/16426498, *Tanijiri T, Shimizu T, Uehira K, Yokoi T, Amuro H, Sugimoto H, Torii Y, Tajima K, Ito T, Amakawa R, Fukuhara S: Hodgkin's reed-sternberg cell line (KM-H2) promotes a bidirectional differentiation of CD4+CD25+Foxp3+ T cells and CD4+ cytotoxic T lymphocytes from CD4+ naive T cells. J Leukoc Biol. 2007 Sep;82 (3) :576-84., URL: https://pubmed.ncbi.nlm.nih.gov/17545218/, *Willett BJ, McMonagle EL, Ridha S, Hosie MJ: Differential utilization of CD134 as a functional receptor by diverse strains of feline immunodeficiency virus. J Virol. 2006 Apr;80 (7) :3386-94., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=willett+bj+mcmonagle+el+ridha+s , *Voo KS, Bover L, Harline ML, Vien LT, Facchinetti V, Arima K, Kwak LW, Liu YJ: Antibodies targeting human OX40 expand effector T cells and block inducible and natural regulatory T cell function. J Immunol. 2013 Oct 1;191 (7) :3641-50., URL: http://www.ncbi.nlm.nih.gov/pubmed/24014877

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody Ber-ACT35 (also known as ACT35) recognizes an extracellular epitope of CD134 (TNFRSF4, OX40), an approximately 50 kDa type I transmembrane glycoprotein expressed on activated T cells.