What is the catalog number for Anti-Hu CD184 APC?

The catalog number for Anti-Hu CD184 APC is 1A-146-T100.

What sizes are available for Anti-Hu CD184 APC?

Anti-Hu CD184 APC is available in the following size(s): 100 Tests.

Is Anti-Hu CD184 APC in stock?

Anti-Hu CD184 APC is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Hu CD184 APC?

Anti-Hu CD184 APC is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Hu CD184 APC?

Estimated delivery time for Anti-Hu CD184 APC is approximately 10 business day(s), depending on your location.

Anti-Hu CD184 APC

CD184, also known as CXCR4 or fusin, is a receptor for the C-X-C chemokine SDF-1. It is expressed mainly in hematopoietic cells, vascular endothelium, and neural tissue. CD184 is a G-protein coupled receptor containing extracellular N-terminal, seven transmembrane domains and intracellular C-terminal domain. It transduces signal by increasing the intracellular calcium level. CD184 plays an essential role in vascularization of the gastrointestinal tract, and is involved in cerebellar development and in hematopoiesis. It is also a coreceptor (with CD4) for HIV-1 X4 virus and a primary receptor for some HIV-2 isolates.

Product Specifications

Certification

RUO

Reactivity

Human, Non-human primates

Immunogen

CP-MAC-infected Sup-T1 cells

Target Antigen

CD184

Clone

12G5

Applications

FC (QC tested)

Format

APC

Buffer

Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Koopman G, Mortier D, Hofman S, Koutsoukos M, Bogers WM, Wahren B, Voss G, Heeney JL: Acute-phase CD4+ T-cell proliferation and CD152 upregulation predict set-point virus replication in vaccinated simian-human immunodeficiency virus strain 89.6p-infected macaques. J Gen Virol. 2009 Apr;90 (Pt 4) :915-26., URL: http://www.ncbi.nlm.nih.gov/pubmed/19223489 , *Campioni D, Zauli G, Gambetti S, Campo G, Cuneo A, Ferrari R, Secchiero P: In vitro characterization of circulating endothelial progenitor cells isolated from patients with acute coronary syndrome. PLoS One. 2013;8 (2) :e56377., URL: http://www.ncbi.nlm.nih.gov/pubmed/23409178 , *Uy GL, Rettig MP, Motabi IH, McFarland K, Trinkaus KM, Hladnik LM, Kulkarni S, Abboud CN, Cashen AF, Stockerl-Goldstein KE, Vij R, Westervelt P, DiPersio JF: A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood. 2012 Apr 26;119 (17) :3917-24., URL: https://pubmed.ncbi.nlm.nih.gov/22308295/, *Grundler R, Brault L, Gasser C, Bullock AN, Dechow T, Woetzel S, Pogacic V, Villa A, Ehret S, Berridge G, Spoo A, Dierks C, Biondi A, Knapp S, Duyster J, Schwaller J: Dissection of PIM serine/threonine kinases in FLT3-ITD-induced leukemogenesis reveals PIM1 as regulator of CXCL12-CXCR4-mediated homing and migration. J Exp Med. 2009 Aug 31;206 (9) :1957-70., URL: https://pubmed.ncbi.nlm.nih.gov/19687226/

Storage Conditions

Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.

Specificity

The mouse monoclonal antibody 12G5 recognizes an extracellular epitope of CD184, a 45 kDa G-protein-linked CXC chemokine receptor widely expressed on blood and tissue cells.