Anti-Hu CD154 Purified Low Endotoxin
CD154 / CD40L (CD40 ligand) is a member of the tumor necrosis factor family, and is expressed primarily on activated CD4+ lymphocytes, but also on mast cells, basophils, eosinophils and human dendritic cells. Its counter-receptor CD40 is expressed on antigen presenting cells, including dendritic cells, macrophages, and B cells, and also on fibroblasts. Triggering of CD40 by CD40L causes maturation of dendritic cells and upregulation of antigen presentation in functions of the MHC and costimulatory molecules. CD40L also functions as a direct stimulating factor for T cells. CD40L plays also roles e.g. in antibody class switching and modulation of apoptosis in the germinal center.
Product Specifications
Certification
RUO
Immunogen
Human CD154 fusion protein
Target Antigen
CD154
Clone
24-31
Applications
FC (QC tested), ICC, FUNC
Concentration
1 mg/mL
Format
Purified Low Endotoxin
Buffer
Phosphate buffered saline (PBS), pH 7.4
References & Citations
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Species
Human, Non-human primates
CAS Number
9007-83-4
Isotype
Mouse IgG1
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