Anti-Hu CD95 Purified Low Endotoxin
CD95 (Fas, APO-1), a 46 kDa transmembrane glycoprotein, is a cell death receptor of the TNFR superfamily. Stimulation of CD95 results in aggregation of its intracellular death domains, formation of the death-inducing signaling complex (DISC) and activation of caspases. In type I cells caspase 3 is activated by high amounts of caspase 8 generated at the DISC, in type II cells low concentration of caspase 8 activates pathway leading to the release of cytochrome c from mitochondria and activation of caspase 3 by cytochom c. Besides its roles in induction of apoptosis, Fas also triggers pro-inflammatory cytokine responses.
Product Specifications
Certification
RUO
Immunogen
P815 cells transfected with human CD95
Target Antigen
CD95
Clone
EOS9.1
Applications
FUNC, FC (QC tested)
Concentration
1 mg/mL
Format
Purified Low Endotoxin
Buffer
Phosphate buffered saline (PBS), pH 7.4
References & Citations
Other References
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Species
Human
CAS Number
9007-83-4
Isotype
Mouse IgM kappa
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