Anti-Insulin Purified Low Endotoxin
Insulin and glucagon are pancreatic endocrine hormones secreted by islet cells within the pancreas. The stimulus for insulin secretion is a HIGH blood glucose. Deficiency of insulin results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population.
Product Specifications
Certification
RUO
Reactivity
Pig, Cow, Human
Immunogen
Porcine insulin.
Target Antigen
Insulin
Clone
IN-05
Applications
ELISA, RIA, IHC-P, ICC, FUNC
Concentration
1 mg/mL
Format
Purified Low Endotoxin
Buffer
Phosphate buffered saline (PBS), pH 7.4
References & Citations
*Horejsi V, Hilgert I, Kristofova H, Satayalai O: Murine hybridoma monoclonal antibodies against insulin: cross-reactivity with insulins of three species and blocking of insulin binding to its receptor. Immunol Lett. 1984;8 (5) :279-83., URL: https://pubmed.ncbi.nlm.nih.gov/6083978/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The antibody IN-05 reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas; it is also present in tumors of B cell origin such as insulinoma.
Applications Notes
Functional application: The antibody IN-05 blocks binding of insulin to the receptor.
Isotype
Mouse IgG1
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