Cetrimonium (bromide)

Cetrimonium bromide (CTAB), a quaternary ammonium, is an orally active cationic surfaetant. Cetrimonium bromide has toxicity and anticancer effect. Cetrimonium bromide inhibits cell migration and invasion through modulating the canonical and non-canonical TGF-β signaling pathways. Cetrimonium bromide can be used for DNA extraction[1][2][3][4].

Product Specifications

CAS Number

[57-09-0]

Product Name Alternative

CTAB; Cetyltrimethylammonium (bromide) ; Hexadecyltrimethylammonium (bromide)

UNSPSC

12352211

Hazard Statement

H302, H315, H318, H335, H373, H410

Target

Apoptosis; Biochemical Assay Reagents; MMP; TGF-β Receptor

Type

Reference compound

Related Pathways

Apoptosis; Metabolic Enzyme/Protease; Others; TGF-beta/Smad

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/Cetrimonium-bromide.html

Purity

98.0

Solubility

DMSO : 10 mg/mL (ultrasonic) |H2O : 4.55 mg/mL (ultrasonic)

Smiles

CCCCCCCCCCCCCCCC[N+](C)(C)C.[Br-]

Molecular Formula

C19H42BrN

Molecular Weight

364.45

Precautions

H302, H315, H318, H335, H373, H410

References & Citations

[1]Wu T K, et al. Cetrimonium bromide inhibits cell migration and invasion of human hepatic SK-HEP-1 cells through modulating the canonical and non-canonical TGF-β signaling pathways [J]. Anticancer research, 2019, 39 (7) : 3621-3631.|[2]Ito E, et al. Potential use of cetrimonium bromide as an apoptosis-promoting anticancer agent for head and neck cancer [J]. Molecular pharmacology, 2009, 76 (5) : 969-983.|[3]Isomaa B, et al. The subacute and chronic toxicity of cetyltrimethylammonium bromide (CTAB), a cationic surfactant, in the rat [J]. Archives of toxicology, 1976, 35: 91-96.|[4]Allen G C, et al. A modified protocol for rapid DNA isolation from plant tissues using cetyltrimethylammonium bromide [J]. Nature protocols, 2006, 1 (5) : 2320-2325.