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Anti-Hu CD85g Purified Low Endotoxin

CD85g / ILT7 (immunoglobulin-like transcript 7) is a cell surface protein that is expressed on plasmacytoid dendritic cells (PDCs) and modulates the function of these cells in the immune response, such as the TLR-induced interferon production. It associates with gamma subunit of the high-affinity IgE receptor to form a receptor complex which transduces the signal through ITAM-associated downstream molecules. Expression of CD85g is downregulated by interleukin 3.

Product Specifications

Certification

RUO

Reactivity

Human

Target Antigen

CD85g

Clone

17G10.2

Applications

FC (QC tested), FUNC

Concentration

1 mg/mL

Format

Purified Low Endotoxin

Buffer

Phosphate buffered saline (PBS), pH 7.4

References & Citations

*Cao W, Rosen DB, Ito T, Bover L, Bao M, Watanabe G, Yao Z, Zhang L, Lanier LL, Liu YJ: Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. J Exp Med. 2006 Jun 12;203 (6) :1399-405., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=cao+w+rosen+db+ito+t+bover+l, *Tavano B, Galao RP, Graham DR, Neil SJ, Aquino VN, Fuchs D, Boasso A: Ig-like transcript 7, but not bone marrow stromal cell antigen 2 (also known as HM1.24, tetherin, or CD317), modulates plasmacytoid dendritic cell function in primary human blood leukocytes. J Immunol. 2013 Mar 15;190 (6) :2622-30., URL: https://pubmed.ncbi.nlm.nih.gov/23401591/, *Tavano B, Boasso A: Effect of immunoglobin-like transcript 7 cross-linking on plasmacytoid dendritic cells differentiation into antigen-presenting cells. PLoS One. 2014 Feb 19;9 (2) :e89414., URL: http://www.ncbi.nlm.nih.gov/pubmed/24586760

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody 17G10.2 recognizes an extracellular epitope of CD85g / ILT7, a member of leukocyte immunoglobulin-like receptor family expressed on plasmacytoid dendritic cells, but not on myeloid dendritic cells and other peripheral blood leukocytes.

Applications Notes

Functional application: Activation. Flow cytometry: Recommended dilution: 1-5 µg/ml

Isotype

Mouse IgG1 kappa

Frequently Asked Questions

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