Anti-Hu CD137 Purified Low Endotoxin
CD137, also known as TNFRSF9 or 4-1BB, is an inducible costimulatory molecule expressed mainly on activated T cells. Its ligand, known as 4-1BBL, is expressed on activated macrophages, mature B cells, hematopoietic stem cells, and myeloid progenitor cells. CD137 signaling leads to maintaining the survival of activated T cells and CD8+ memory T cells, and clonal expansion of T cells, but also to suppressing myelopoiesis and dendritic cell development. Triggered CD137 induces a cytokine release profile regulating peripheral monocyte survival. Soluble forms of CD137 may provide negative control mechanism for some immune responses.
Product Specifications
Certification
RUO
Reactivity
Human, Non-human primates
Immunogen
Recombinant human CD137 ectodomain
Target Antigen
CD137
Clone
4B4-1
Applications
FC (QC tested), IP, ELISA, FUNC
Concentration
1 mg/mL
Format
Purified Low Endotoxin
Buffer
Phosphate buffered saline (PBS), pH 7.4
References & Citations
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Applications Notes
Functional application: Inhibition of cytokine production. Flow cytometry: Recommended dilution: 1-4 µg/ml
Isotype
Mouse IgG1 kappa
Frequently Asked Questions
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