What is the catalog number for Anti-Ms CD49e Purified?

The catalog number for Anti-Ms CD49e Purified is 11-743-C100.

What sizes are available for Anti-Ms CD49e Purified?

Anti-Ms CD49e Purified is available in the following size(s): 0.1 mg.

Is Anti-Ms CD49e Purified in stock?

Anti-Ms CD49e Purified is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Ms CD49e Purified?

Anti-Ms CD49e Purified is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Ms CD49e Purified?

Estimated delivery time for Anti-Ms CD49e Purified is approximately 10 business day(s), depending on your location.

Anti-Ms CD49e Purified

CD49e, the alpha 5 integrin, noncovalently associates with the beta 1integrin (CD29) to form VLA-5 integrin complex. CD49e itself is composed of two disulfide-linked chains of 135 kDa and 25 kDa. VLA-5 binds to RGD sequence of fibronectin, and to neural adhesion molecule L1. It is important in maintaining the integrity of endothelial monolayers, in monocyte migration into the extracellular tissues, and it also provides a co-stimulatory signal to T cells and enhances receptor and complement receptor-mediated phagocytosis.

Product Specifications

Certification

RUO

Reactivity

Mouse

Immunogen

C57BL/6 x A/J) F1 murine mast cell line

Target Antigen

CD49e

Clone

5H10-27 (MFR5)

Applications

ICC, FC (QC tested), IHC-F

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*van der Loo JC, Xiao X, McMillin D, Hashino K, Kato I, Williams DA: VLA-5 is expressed by mouse and human long-term repopulating hematopoietic cells and mediates adhesion to extracellular matrix protein fibronectin. J Clin Invest. 1998 Sep 1;102 (5) :1051-61., URL: https://pubmed.ncbi.nlm.nih.gov/9727075/, *Sampaio AL, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M: Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis. J Leukoc Biol. 2010 May;87 (5) :877-84., URL: https://pubmed.ncbi.nlm.nih.gov/20097849/, *Plett PA, Frankovitz SM, Orschell CM: Distribution of marrow repopulating cells between bone marrow and spleen early after transplantation. Blood. 2003 Sep 15;102 (6) :2285-91., URL: http://www.ncbi.nlm.nih.gov/pubmed/12775569

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The rat monoclonal antibody 5H10-27 (MFR5) recognizes an extracellular epitope of murine CD49e, a 135 kDa protein serving as VLA-5 alpha chain, expressed on thymocytes, activated T cells, splenic B cells, and mast cells.