Anti-Granzyme B Purified
Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.
Product Specifications
Certification
RUO
Immunogen
Human NK cell line YT-INDY-derived granzyme B
Target Antigen
Granzyme B
Clone
CLB-GB11
Applications
FC (QC tested)
Concentration
1 mg/mL
Format
Purified
Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
References & Citations
Other References
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml. Intracellular staining.
Species
Non-human primates, Human
CAS Number
9007-83-4
Isotype
Mouse IgG1
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items