Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-ABRA1 Purified

ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.

Product Specifications

Certification

RUO

Immunogen

Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag

Target Antigen

ABRA1

Clone

ABRA1-01

Applications

IP, WB, FC-IC

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Nikkilä J, Coleman KA, Morrissey D, Pylkäs K, Erkko H, Messick TE, Karppinen SM, Amelina A, Winqvist R, Greenberg RA: Familial breast cancer screening reveals an alteration in the RAP80 UIM domain that impairs DNA damage response function. Oncogene. 2009 Apr 23;28 (16) :1843-52., URL: https://www.ncbi.nlm.nih.gov/pubmed/19305427, *Wang B, Elledge SJ: Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc Natl Acad Sci U S A. 2007 Dec 26;104 (52) :20759-63., URL: https://www.ncbi.nlm.nih.gov/pubmed/18077395, *Liu Z, Wu J, Yu X: CCDC98 targets BRCA1 to DNA damage sites. Nat Struct Mol Biol. 2007 Aug;14 (8) :716-20., URL: https://www.ncbi.nlm.nih.gov/pubmed/17643121, *Wang B, Matsuoka S, Ballif BA, Zhang D, Smogorzewska A, Gygi SP, Elledge SJ: Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response. Science. 2007 May 25;316 (5828) :1194-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/17525340

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody ABRA1-01 recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG2a kappa

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

Mouse LOC668415 activation kit by CRISPRa
GA218471 1 Kit

Mouse LOC668415 activation kit by CRISPRa

Ask
View Details
APOA2 3'UTR Lenti-reporter-Luc Vector
12158081 1.0 μg

APOA2 3'UTR Lenti-reporter-Luc Vector

Ask
View Details
CLK4 siRNA (m)
sc-142394 10 µM

CLK4 siRNA (m)

Ask
View Details
DNAI1 Protein Lysate (Human) with C-Ha Tag
18361031 100 μg

DNAI1 Protein Lysate (Human) with C-Ha Tag

Ask
View Details
Goose Neutrophil Activating Protein-2 ELISA Kit
MBS043847 Inquire

Goose Neutrophil Activating Protein-2 ELISA Kit

Ask
View Details
Recombinant Haemophilus ducreyi UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (murG)
MBS1375461-01 0.02 mg (E-Coli)

Recombinant Haemophilus ducreyi UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (murG)

Ask
View Details