Anti-AGR3 Purified
AGR3 (Anterior Gradient 3) protein, also known as AG3 (hAG-3, HAG3 in human), or BCMP11, is a secreted cytoplasmic protein which is involved in metastasis induction and p53 tumour supressor inhibition. It may serve as molecular marker and potential therapeutic target for hormone-responsive breast tumours. Its Xenopus homolog is associated with anteroposterior fate determination during early development.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Purified human AGR3 protein
Target Antigen
AGR3
Clone
AGR3.1
Applications
WB, IHC-P, IHC-F, ICC
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Obacz J, Brychtová V, Podhorec J, Fabian P, Dobeš P, Vojtěšek B, Hrstka R: Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients. Onco Targets Ther. 2015 Jun 24;8:1523-32., URL: https://pubmed.ncbi.nlm.nih.gov/26170690/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The antibody AGR3.1 recognizes the epitope HETTDKNLS within the AGR3 (AG3) protein (19-20 kDa) ; a secreted cytoplasmic protein which can serve as a marker of carcinogenesis.
Applications Notes
Immunohistochemistry (paraffin sections) : Recommended dilution: 1 μg/ml; positive tissue: breast cancer. Immunohistochemistry (frozen sections) : Recommended dilution: 1 μg/ml; positive tissue: breast cancer. Western blotting: Recommended dilution: 1 μg/ml; positive control: T47D breast cancer cell line, negative control: H1299 lung carcinoma cell line. Immunocytochemistry: Recommended dilution: 1 μg/ml; positive control: T47D breast cancer cell line, negative control: H1299 lung carcinoma cell line.
Isotype
Mouse IgG1
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