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Anti-AGR3 Purified

AGR3 (Anterior Gradient 3) protein, also known as AG3 (hAG-3, HAG3 in human), or BCMP11, is a secreted cytoplasmic protein which is involved in metastasis induction and p53 tumour supressor inhibition. It may serve as molecular marker and potential therapeutic target for hormone-responsive breast tumours. Its Xenopus homolog is associated with anteroposterior fate determination during early development.

Product Specifications

Certification

RUO

Immunogen

Purified human AGR3 protein

Target Antigen

AGR3

Clone

AGR3.1

Applications

WB, IHC-P, IHC-F, ICC

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Obacz J, Brychtová V, Podhorec J, Fabian P, Dobeš P, Vojtěšek B, Hrstka R: Anterior gradient protein 3 is associated with less aggressive tumors and better outcome of breast cancer patients. Onco Targets Ther. 2015 Jun 24;8:1523-32., URL: https://pubmed.ncbi.nlm.nih.gov/26170690/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The antibody AGR3.1 recognizes the epitope HETTDKNLS within the AGR3 (AG3) protein (19-20 kDa) ; a secreted cytoplasmic protein which can serve as a marker of carcinogenesis.

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG1

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