Anti-Hu CD79a Purified
CD79a (Ig alpha, MB1) forms disulfide-linked heterodimer with CD79b (Ig beta) . They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR) . CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. At the plasma cell stage, CD79a is present as an intracellular component. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling.
Product Specifications
Certification
RUO
Immunogen
Synthetic peptide corresponding to amino acids 202-216 of human CD79a
Target Antigen
CD79a
Clone
HM57
Applications
FC (QC tested), IHC-F (reported), IHC-P (reported)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Other References
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Species
Chicken, Rabbit, Opossum, Guinea pig, Horse, Cow, Pig, Mouse, Rat, Human
CAS Number
9007-83-4
Isotype
Mouse IgG1
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