Anti-Hu Ig Kappa Light Chain Purified

Immunoglobulin classes share the same basic four polypeptide chain structure of two heavy chains (five heavy chains types) and two light chains (kappa, lambda; both having a molecular weight of 22.5kDa) . Kappa and lambda consist of a variable region and a constant region and can easily be differentiated by the antigenic properties of the constant region. The ratio of kappa to lambda is 70:30.

Product Specifications

Certification

RUO

Negative Species

Rabbit,Hamster,Sheep,Guinea pig,Goat

Reactivity

Human

Target Antigen

Ig Kappa Light Chain

Clone

A8B5

Applications

FC (QC tested), IHC-P, IHC-F, ELISA

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Diaz de Domingo NB, Lardo MM, Romero Artaza J, Merelli A, Carbia CD, Sánchez Avalos JC: Aplicacion de tecnicas inmunocitoquimicas para el diagnostico de neoplasias hematologicas. Medicina (B Aires) . 1999;59 (1) :11-6., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=lardo+mm+artaza+jr+merelli+a , *Scheeren FA, Diehl SA, Smit LA, Beaumont T, Naspetti M, Bende RJ, Blom B, Karube K, Ohshima K, van Noesel CJ, Spits H: IL-21 is expressed in Hodgkin lymphoma and activates STAT5: evidence that activated STAT5 is required for Hodgkin lymphomagenesis. Blood. 2008 May 1;111 (9) :4706-15. doi: 10.1182/blood-2007-08-105643, URL: http://www.ncbi.nlm.nih.gov/pubmed/18296629 , *Di Bartolo DL, Hyjek E, Keller S, Guasparri I, Deng H, Sun R, Chadburn A, Knowles DM, Cesarman E: Role of defective Oct-2 and OCA-B expression in immunoglobulin production and Kaposi's sarcoma-associated herpesvirus lytic reactivation in primary effusion lymphoma. J Virol. 2009 May;83 (9) :4308-15. doi: 10.1128/JVI.02196-08., URL: http://www.ncbi.nlm.nih.gov/pubmed/19224997 , *Konig A, Wennemuth G, Soyer HP, Hoffmann R, Happle R, Krause W: Vulvar amyloidosis mimicking giant condylomata acuminata in a patient with multiple myeloma. Eur J Dermatol. 1999 Jan-Feb;9 (1) :29-31., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=konig+a+wennemuth+g+soyer+hp, *Avilés-Salas A, Chanona-Vilchis JG, Candelaria-Hernández MG, Peñ a-Torres Mde L, Cuéllar-Mendoza ME: Presentación inicial de un linfoma plasmablástico como tumor ovárico. Ginecol Obstet Mex. 2012 Jun;80 (6) :430-4., URL: http://www.ncbi.nlm.nih.gov/pubmed/22826973

Other References

*Franklin EC: Structure and function of immunoglobulins. Acta Endocrinol Suppl (Copenh) . 1975;194:77-95., URL: https://www.ncbi.nlm.nih.gov/pubmed/47690?ordinalp