Anti-NTAL Purified

NTAL (non-T cell activation linker), also known as LAB (linker for activation of B cells), is a 30 kDa double-palmitoylated transmembrane adaptor protein expressed by B cells, NK cells, mast cells and macrophages. It is a negative regulator of early stages of BCR-dependent B cell signaling and serves as a negative regulator also in mast cells. However, in mast cells, NTAL also contributes to some activation processes, partially overlapping with LAT function.

Product Specifications

Certification

RUO

Negative Species

Human

Reactivity

Mouse

Immunogen

Recombinant N-terminal cytoplasmic domain (aa 124-203) of mouse NTAL.

Target Antigen

NTAL

Clone

PAb (486)

Applications

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Volná P, Lebduška P, Dráberová L, Šímová S, Heneberg P, Boubelík M, Bugajev V, Malissen B, Wilson BS, Horejsí V, Malissen M, Dráber P: Negative regulation of mast cell signaling and function by the adaptor LAB/NTAL. J Exp Med. 2004 Oct 18;200 (8) :1001-13., URL: https://pubmed.ncbi.nlm.nih.gov/15477348/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The polyclonal antibody recognizes N-terminal cytoplasmic domain of mouse Non-T cell Activation Linker (NTAL), also known as LAB (linker of activated B cells), a 25 kDa transmembrane adaptor protein present in membrane microdomains (rafts) of B cells, NK cells and myeloid cells.