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Anti-Hu Tenascin C Purified

Tenascin C is an approximately 250 kDa extracellular matrix glycoprotein with important roles in the nervous system, as it promotes correct migration of growing axons during development and during neuronal regeneration. It is also involved in synaptic plasticity. Ligands of tenascin C are integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3, and alpha-V/beta-6. Similarly to neural cells, it also stimulates angiogenesis by promoting elongation and migration of endothelial cells.

Product Specifications

Certification

RUO

Immunogen

Protein preparation from a homogenate of a human mammary tumour specimen.

Target Antigen

Tenascin C

Clone

T2H5

Applications

IHC-P, IP, WB

Concentration

1 mg/mL

Format

Purified

Buffer

Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

References & Citations

*Ioachim E, Charchanti A, Briasoulis E, Karavasilis V, Tsanou H, Arvanitis DL, Agnantis NJ, Pavlidis N: Immunohistochemical expression of extracellular matrix components tenascin, fibronectin, collagen type IV and laminin in breast cancer: their prognostic value and role in tumour invasion and progression. Eur J Cancer. 2002 Dec;38 (18) :2362-70. , URL: https://www.ncbi.nlm.nih.gov/pubmed/12460779?dopt=, *Gulubova M: Immunohistochemical localization of collagen type III and type IV, laminin, tenascin and alpha-smooth muscle actin (alphaSMA) in the human liver in peliosis. Pathol Res Pract. 2002;198 (12) :803-12., URL: https://www.ncbi.nlm.nih.gov/pubmed/12608657?dopt=, *Faustino AM, van Garderen E, Schalken JA, Nederbragt H: Tenascin expression in normal, hyperplastic, dysplastic and neoplastic canine mammary tissues. J Comp Pathol. 2002 Jan;126 (1) :1-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/11814316?dopt=, *Tokes AM, Hortovanyi E, Csordas G, Kulka J, Mozes G, Hatalyak A, Kadar A: Immunohistochemical localisation of tenascin in invasive ductal carcinoma of the breast. Anticancer Res. 1999 Jan-Feb;19 (1A) :175-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/10226540?dopt=, *Bhattacharyya S, Wang W, Morales-Nebreda L, Feng G, Wu M, Zhou X, Lafyatis R, Lee J, Hinchcliff M, Feghali-Bostwick C, Lakota K, Scott Budinger GS, Raparia K, Tamaki Z, Varga J: Tenascin-C drives persistence of organ fibrosis. Nat Commun. 2016 Jun 3;7:11703, URL: https://pubmed.ncbi.nlm.nih.gov/27256716/, *Seyger MM, van Bruggen MC, Hardeman HK, van den Hoogen FH, Berden JH, van den Born J, de Jong EM: Decreased staining of heparan sulfate in non-lesional skin of a subgroup of patients with systemic lupus erythematosus. Acta Derm Venereol. 1998 Sep;78 (5) :326-30., URL: https://pubmed.ncbi.nlm.nih.gov/9779246/, *Le Poole IC, van den Wijngaard RM, Westerhof W, Das PK: Tenascin is overexpressed in vitiligo lesional skin and inhibits melanocyte adhesion. Br J Dermatol. 1997 Aug;137 (2) :171-8 , URL: https://pubmed.ncbi.nlm.nih.gov/9292062/, *Verstraeten AA, Mackie EJ, Hageman PC, Hilgers J, Schol DJ, de Jongh GJ, Schalkwijk J: Tenascin expression in basal cell carcinoma. Br J Dermatol. 1992 Dec;127 (6) :571-4, URL: https://pubmed.ncbi.nlm.nih.gov/1282358/, *Mansour RG, Stamper L, Jaeger F, McGuire E, Fouda G, Amos J, Barbas K, Ohashi T, Alam SM, Erickson H, Permar SR: The presence and anti-HIV-1 function of tenascin C in breast milk and genital fluids. PLoS One. 2016 May 16;11 (5) :e0155261. , URL: https://pubmed.ncbi.nlm.nih.gov/27182834/, *Latijnhouwers MA, Bergers M, Kuijpers AL, van der Vleuten CJ, Dijkman H, van de Kerkhof PC, J Schalkwijk: Tenascin-C is not a useful marker for disease activity in psoriasis. Acta Derm Venereol. 1998 Sep;78 (5) :331-4., URL: https://pubmed.ncbi.nlm.nih.gov/9779247/, *Schalkwijk J, Zweers MC, Steijlen PM, Dean WB, Taylor G, van Vlijmen IM, van Haren B, Miller WL, Bristow J: A recessive form of the Ehlers-Danlos syndrome caused by tenascin-X deficiency. N Engl J Med. 2001 Oct 18;345 (16) :1167-75., URL: https://pubmed.ncbi.nlm.nih.gov/11642233/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The antibody T2H5 recognizes tenascin C, a large hexameric extracellular matrix glycoprotein.

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG1

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