Anti-Bov CD41/CD61 Purified

*Mateo A, Pintado CO, Perez de la Lastra J, Dusinsky R, Simon M, Naessens J, Llanes D: Ruminant cluster CD41/CD61. Vet Immunol Immunopathol. 1996 Aug;52 (4) :251-3., URL: https://www.ncbi.nlm.nih.gov/pubmed/8896208?dopt=A, *Naessens J, Howard CJ, Hopkins J: Nomenclature and characterization of leukocyte differentiation antigens in ruminants. Immunol Today. 1997 Aug;18 (8) :365-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/9267076?dopt=A, *Mateo A, Perez de la Lastra J, Moreno A, Dusinsky R, Bilka F, Simon M, Horovska L, Llanes D: Biochemical characterization of antigens detected with anti-platelet monoclonal antibodies. Vet Immunol Immunopathol. 1996 Aug;52 (4) :363-70., URL: https://www.ncbi.nlm.nih.gov/pubmed/8896226?dopt=A, *Naessens J & Hopkins J: Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995. Vet Immunol Immunopathol 52:213-468 (1996) ., URL: https://www.ncbi.nlm.nih.gov/pubmed/8896204?dopt=A, *Simon M, Dusinsky R, Horovska L, Bilka F, Hluchy S: Immunohistochemical reactivity of anti-platelet monoclonal antibodies. Vet Immunol Immunopathol. 1996 Aug;52 (4) :377-82., URL: https://www.ncbi.nlm.nih.gov/pubmed/8896228?dopt=A

The antibody IVA30 reacts with an extracellular epitope on CD41/CD61 complex (bovine), one of the earliest markers of the megakaryocytic lineage. CD41/CD61 complex acts as the receptor for fibrinogen, fibronectin, Von Willebrand factor, vitronectin, thrombin and mediates platelets aggregation. CD41/CD61 is expressed only by platelets and megakaryocytes; the complex may be absent or strongly reduced in Glanzmann's thrombasthenia (GT) . This antibody crossreacts with human platelets.