Anti-Bov CD45R Purified
CD45R, also known as B220, is a receptor-type protein tyrosine phosphatase glycoprotein. It is crucial in lymphocyte development and antigen signaling, serving as an important regulator of Src-family kinases, promotes cell survival by modulating integrin-mediated signal transduction pathway and is also involved in DNA fragmentation during apoptosis. CD45R expression also identifies a subset of murine bone marrow cells able to form osteoclast-like cells.
Product Specifications
Certification
RUO
Reactivity
Cow
Immunogen
Bovine leukocytes.
Target Antigen
CD45R
Clone
IVA103
Applications
FC, IP, ICC
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Naessens J, Howard CJ, Hopkins J: Nomenclature and characterization of leukocyte differentiation antigens in ruminants. Immunol Today. 1997 Aug;18 (8) :365-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/9267076?dopt=A, *Naessens J & Hopkins J: Proceedings of the 3rd workshop on ruminant leukocyte antigens. Davis, California, 16 July 1995. Vet Immunol Immunopathol 52:213-468 (1996) ., URL: https://www.ncbi.nlm.nih.gov/pubmed/8896204?dopt=A, *Sopp P, Howard CJ: Investigation of PC36 (BoCD45R) . Vet Immunol Immunopathol. 1996 Aug;52 (4) :271-4., URL: https://www.ncbi.nlm.nih.gov/pubmed/8896215?dopt=A
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The antibody IVA103 reacts with an extracellular epitope of CD45R antigen (bovine), a single chain type I transmembrane glycoprotein (member of the protein tyrosine phosphatase family), a restricted form of the CD45 family. CD45R is an essential regulator of T and B lymphocytes antigen receptor signaling and it is specifically expressed in hematopoietic cells.
Applications Notes
Flow cytometry: Recommended dilution: 1-4 μg/ml.
Isotype
Mouse IgG1
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