Anti-TRIM Purified
TRIM (T cell receptor-interacting molecule), also known as TRAT1 (T cell receptor associated transmembrane adaptor 1) is a 30 kDa protein expressed by T cells as a cystein-linked homodimer. It associates with TCR-CD3-zeta-chain complex and becomes phosphorylated by Src-family kinases. TRIM is potentially involved in negative regulation of TCR-mediated signaling, but its role remains unclear.
Product Specifications
Certification
RUO
Negative Species
Mouse
Immunogen
Recombinant intracellular domain (aa 29-186) of human TRIM.
Target Antigen
TRIM
Clone
TRIM-04
Applications
IP, WB, FC-IC
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Kirchgessner H, Dietrich J, Scherer J, Isomaki P, Korinek V, Hilgert I, Bruyns E, Leo A, Cope AP, Schraven B.: The transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain. J Exp Med. 2001 Jun 4;193 (11) :1269-84. , URL: https://www.ncbi.nlm.nih.gov/pubmed/11390434?dopt=
Other References
*Tedoldi S, Paterson JC, Hansmann ML, Natkunam Y, Rüdiger T, Angelisova P, Du MQ, Roberton H, Roncador G, Sanchez L, Pozzobon M, Masir N, Barry R, Pileri S, Mason DY, Marafioti T, Horejsí V: Transmembrane adaptor molecules: a new category of lymphoid-cell markers. Blood. 2006 Jan 1;107 (1) :213-21., URL: https://pubmed.ncbi.nlm.nih.gov/16160011/, *Simeoni L, Smida M, Posevitz V, Schraven B, Lindquist JA: Right time, right place: the organization of membrane proximal signaling. Semin Immunol. 2005 Feb;17 (1) :35-49., URL: https://pubmed.ncbi.nlm.nih.gov/15582487/, *Huynh T, Wurch A, Bruyns E, Korinek V, Schraven B, Eichmann K: Developmentally regulated expression of the transmembrane adaptor protein trim in fetal and adult T cells. Scand J Immunol. 2001 Jul-Aug;54 (1-2) :146-54., URL: https://www.ncbi.nlm.nih.gov/pubmed/11439161?dopt=, *Horejsí V, Zhang W, Schraven B: Transmembrane adaptor proteins: organizers of immunoreceptor signalling. Nat Rev Immunol. 2004 Aug;4 (8) :603-16., URL: https://pubmed.ncbi.nlm.nih.gov/15286727/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The antibody TRIM-04 recognizes an intracellular epitope of T cell receptor-interacting molecule (TRIM), a 30 kDa adaptor protein expressed by T cells.
Species
Human
CAS Number
9007-83-4
Isotype
Mouse IgG2a
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
41584121 3 x 1.0μg DNA
RPL36AP7 CRISPRa sgRNA lentivector (set of three targets)(Human)
Ask
View Details 