Anti-LCK Purified
Product Specifications
Clone
LCK-01
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Cebecauer M, Cerny J, Horejsi V.: Incorporation of leucocyte GPI-anchored proteins and protein tyrosine kinases into lipid-rich membrane domains of COS-7 cells. Biochem Biophys Res Commun. 1998 Feb 24;243 (3) :706-10., URL: https://www.ncbi.nlm.nih.gov/pubmed/9500981?dopt=A, *Romagnoli P, Strahan D, Pelosi M, Cantagrel A, van Meerwijk JP.: A potential role for protein tyrosine kinase p56 (lck) in rheumatoid arthritis synovial fluid T lymphocyte hyporesponsiveness. Int Immunol. 2001 Mar;13 (3) :305-12., URL: https://www.ncbi.nlm.nih.gov/pubmed/11222499?dopt=, *Meraner P, Horejsí V, Wolpl A, Fischer GF, Stingl G, Maurer D: Dendritic cells sensitize TCRs through self-MHC-mediated Src family kinase activation. J Immunol. 2007 Feb 15;178 (4) :2262-71., URL: https://www.ncbi.nlm.nih.gov/pubmed/17277131?ordin, *Brdicková N, Brdicka T, Angelisová P, Horváth O, Spicka J, Hilgert I, Paces J, Simeoni L, Kliche S, Merten C, Schraven B, Horejsí V: LIME: a new membrane Raft-associated adaptor protein involved in CD4 and CD8 coreceptor signaling. J Exp Med. 2003 Nov 17;198 (10) :1453-62., URL: http://www.ncbi.nlm.nih.gov/pubmed/14610046?itool=
Other References
*Denny MF, Kaufman HC, Chan AC, Straus DB: The lck SH3 domain is required for activation of the mitogen-activated protein kinase pathway but not the initiation of T-cell antigen receptor signaling. J Biol Chem. 1999 Feb 19;274 (8) :5146-52., URL: https://www.ncbi.nlm.nih.gov/pubmed/9988764?ordina, *Gruber C, Henkel M, Budach W, Belka C, Jendrossek V: Involvement of tyrosine kinase p56/Lck in apoptosis induction by anticancer drugs. Biochem Pharmacol. 2004 May 15;67 (10) :1859-72., URL: https://www.ncbi.nlm.nih.gov/pubmed/15130763?ordin, *Hur YG, Yun Y, Won J: Rosmarinic acid induces p56lck-dependent apoptosis in Jurkat and peripheral T cells via mitochondrial pathway independent from Fas/Fas ligand interaction. J Immunol. 2004 Jan 1;172 (1) :79-87., URL: https://www.ncbi.nlm.nih.gov/pubmed/14688312?ordin, *Lovatt M, Filby A, Parravicini V, Werlen G, Palmer E, Zamoyska R: Lck regulates the threshold of activation in primary T cells, while both Lck and Fyn contribute to the magnitude of the extracellular signal-related kinase response. Mol Cell Biol. 2006 Nov;26 (22) :8655-65., URL: https://www.ncbi.nlm.nih.gov/pubmed/16966372?ordin, *Kim MJ, Park MT, Yoon CH, Byun JY, Lee SJ: Activation of Lck is critically required for sphingosine-induced conformational activation of Bak and mitochondrial cell death. Biochem Biophys Res Commun. 2008 May 30;370 (2) :353-8., URL: https://www.ncbi.nlm.nih.gov/pubmed/18371298?ordin, *Li M, Ong SS, Rajwa B, Thieu VT, Geahlen RL, Harrison ML: The SH3 domain of Lck modulates T-cell receptor-dependent activation of extracellular signal-regulated kinase through activation of Raf-1. Mol Cell Biol. 2008 Jan;28 (2) :630-41., URL: https://www.ncbi.nlm.nih.gov/pubmed/17998336?ordin
CAS Number
9007-83-4
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