Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-alpha-Fetoprotein Purified

Alpha-fetoprotein (AFP) is present in fetal plasma, and it binds e.g. copper, nickel, and bilirubin. Measuring of alpha-fetoprotein level in amniotic fluid can reveal severe fetal defects. In adults, elevated AFP concentrations in the plasma can indicate hepatocellular carcinoma or teratoblastoma. In some individuals, hereditary persistance of alpha-fetoprotein can be observed without any obvious pathology.

Product Specifications

Certification

RUO

Immunogen

Purified alpha-Fetoprotein

Target Antigen

Alpha-Fetoprotein

Clone

AFP-01

Applications

IP, ELISA, WB, ICC

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Stefanova I, Horejsi V, Kristofova H, Angelisova P, Zizkovsky V, Hilgert I: Monoclonal antibodies against human alpha-fetoprotein. Exploitation of an unusual calcium-dependent interaction with the antigen for analytical and preparative purposes. J Immunol Methods. 1988 Jun 28;111 (1) :67-73., URL: https://www.ncbi.nlm.nih.gov/pubmed/2455753?dopt=A, *Cavin LG, Venkatraman M, Factor VM, Kaur S, Schroeder I, Mercurio F, Beg AA, Thorgeirsson SS, Arsura M: Regulation of alpha-fetoprotein by nuclear factor-kappaB protects hepatocytes from tumor necrosis factor-alpha cytotoxicity during fetal liver development and hepatic oncogenesis. Cancer Res. 2004 Oct 1;64 (19) :7030-8. , URL: https://www.ncbi.nlm.nih.gov/pubmed/15466196?dopt=, *Cermák L, Símová S, Pintzas A, Horejsí V, Andera L: Molecular mechanisms involved in CD43-mediated apoptosis of TF-1 cells. Roles of transcription Daxx expression, and adhesion molecules. J Biol Chem. 2002 Mar 8;277 (10) :7955-61., URL: http://www.ncbi.nlm.nih.gov/pubmed?term=%C4%8Derm%C3%A1k%20l%20%C5%A1%C3%ADmov%C3%A1%20%C5%A1%20pintzas%20a , *Green CJ, Charlton CA, Wang LM, Silva M, Morten KJ, Hodson L: The isolation of primary hepatocytes from human tissue: optimising the use of small non-encapsulated liver resection surplus. Cell Tissue Bank 2017 Dec;18 (4) :597-604., URL: https://pubmed.ncbi.nlm.nih.gov/28717878/, *Colquhoun DR, Goldman LR, Cole RN, Gucek M, Mansharamani M, Witter FR, Apelberg BJ, Halden RU: Global screening of human cord blood proteomes for biomarkers of toxic exposure and effect. Environ Health Perspect. 2009 May;117 (5) :832-8., URL: https://pubmed.ncbi.nlm.nih.gov/19478969/, *Wang Z, Bi B, Song H, Liu L, Zheng H, Wang S, Shen Z: Proliferation of human hepatocellular carcinoma cells from surgically resected specimens under conditionally reprogrammed culture. Mol Med Rep. 2019 Jun;19 (6) :4623-4630., URL: https://pubmed.ncbi.nlm.nih.gov/31059040/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody AFP-01 reacts with human alpha-Fetoprotein (AFP), a 70 kDa oncofetal antigen. AFP is a major fetal plasma protein, but is not present in healthy adult tissues. Elevated AFP concentrations in adult plasma may be an early marker of hepatocellular carcinoma or teratoblastoma, while high concentrations in amniotic fluid may indicate severe congenital defects of a fetus.

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG1

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

ZNF827 AAV siRNA Pooled Vector
51867161 1.0 μg

ZNF827 AAV siRNA Pooled Vector

Ask
View Details
Nori Bovine S100A8 ELISA Kit
GR112322 96 Well

Nori Bovine S100A8 ELISA Kit

Ask
View Details
Rabbit Polyclonal RNF11 Antibody
NBP2-95247-0.02mL 0.02 mL

Rabbit Polyclonal RNF11 Antibody

Ask
View Details
Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) PPQ1 Polyclonal Antibody
MBS7155211 Inquire

Rabbit anti-Saccharomyces cerevisiae (strain 204508/S288c)(Baker's yeast) PPQ1 Polyclonal Antibody

Ask
View Details
Tubulin Delta 1 (TUBD1) Antibody (HRP)
abx338104-01 20 µg

Tubulin Delta 1 (TUBD1) Antibody (HRP)

Ask
View Details
Tubulin Delta 1 (TUBD1) Antibody (HRP)
abx338104-02 50 µg

Tubulin Delta 1 (TUBD1) Antibody (HRP)

Ask
View Details