Anti-HLA Class I Purified
HLA-class I major histocompatibility (MHC) antigens are intrinsic membrane glycoproteins expressed on nucleated cells and noncovalently associated with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence. Human HLA-class I antigens are represented by HLA-A, HLA-B and HLA-C molecules.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Leukocytes of a patient suffering with LGL type leukemia.
Target Antigen
HLA Class I
Clone
MEM-81
Applications
FC (QC tested)
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
*Valenzuela NM, Mulder A, Reed EF: HLA class I antibodies trigger increased adherence of monocytes to endothelial cells by eliciting an increase in endothelial P-selectin and, depending on subclass, by engaging Fcγ Rs. J Immunol. 2013 Jun 15;190 (12) :6635-50. , URL: https://www.ncbi.nlm.nih.gov/pubmed/23690477
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The antibody MEM-81 reacts with an extracellular epitope on human classical MHC Class I molecules in native cell-surface forms. MHC Class I molecules (MHC Class Ia) are expressed on the surface of human nucleated cell types.
Applications Notes
Flow cytometry: Recommended dilution: 1-5 μg/ml.
Isotype
Mouse IgG1
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