Anti-HLA-DR Purified
HLA-DR, a member of MHC class II glycoproteins, that bind intracellularly processed peptides and present them to the Th cells, is composed of 36 kDa alpha chain and 27 kDa beta chain, both anchored in the plasma membrane. Together with other MHC II molecules HLA-DR plays a central role in the immune system.
Product Specifications
Certification
RUO
Reactivity
Human
Immunogen
Raji Burkitt's lymphoma cell line
Target Antigen
HLA-DR
Clone
HL-39
Applications
FC (QC tested), IP
Concentration
1 mg/mL
Format
Purified
Buffer
Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
References & Citations
*Horejsi V, Nemec M, Angelisova P, Kristofova H, Gorga JC, Hilgert I: Characterization of seven new monoclonal antibodies against human DR, DR + DP and DQ1 + DQ3 antigens. Tissue Antigens. 1986 Nov;28 (5) :288-97. , URL: https://www.ncbi.nlm.nih.gov/pubmed/2435017?dopt=A, *Hovden AO, Karlsen M, Jonsson R, Aarstad HJ, Appel S: Maturation of monocyte derived dendritic cells with OK432 boosts IL-12p70 secretion and conveys strong T-cell responses. BMC Immunol. 2011 Jan 5;12:2., URL: http://www.ncbi.nlm.nih.gov/pubmed/21208424
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The antibody HL-39 recognizes an extracellular common epitope on human HLA-DR, which is dependent on the association of alpha and beta chains. Recognized epitope is conserved after fixation with glutaraldehyde and formaldehyde. DR is the isotype of human MHC Class II molecules expressed on antigen-presenting cells (APC; dendritic cells, B lymphocytes, monocytes, macrophages) .
Applications Notes
Flow cytometry: Recommended dilution: 0.5-4 μg/ml.
Isotype
Mouse IgG3
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