PARP1/2-IN-3
PARP1/2-IN-3 (Compound 29) is an orally active inhibitor for PARP 1 and PARP 2 with IC50 of 0.2235 nM and IC50 of 1.82-9.98 nM. PARP1/2-IN-3 exhibits antitumor efficacy in mice[1].
Product Specifications
CAS Number
3032451-58-1
UNSPSC
12352005
Target
PARP
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/parp1-2-in-3.html
Smiles
CC1=CC=C(O1)C2=NN=C3CN(CCN32)C(C4=CC(CC5=NNC(C6=C5C=CC=C6)=O)=CC=C4F)=O
Molecular Formula
C26H21FN6O3
Molecular Weight
484.48
References & Citations
[1]Yang Chun, et al., Phthalazinone or quinazolinone derivatives, pharmaceutical compositions and uses thereof. CN118324766A
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PARP1
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