Anti-Acr2 (M. tuberculosis) Purified
The Mycobacterium tuberculosis antigen Acr2 (alpha-crystallin-related protein 2), also known as HrpA or Hsp20, is a small heat shock protein, which forms oligomeric assemblies. Expression of Acr2 is induced by heat shock, oxidative stress, and uptake by macrophages. It evokes a vigorous early immune response.
Product Specifications
Certification
RUO
Reactivity
Mycobacterium tuberculosis
Immunogen
Recombinant Acr2 protein (produced in E. coli)
Target Antigen
Acr2 (M. tuberculosis)
Clone
PAb (188)
Applications
WB, ELISA
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Other References
*Stewart GR, Newton SM, Wilkinson KA, Humphreys IR, Murphy HN, Robertson BD, Wilkinson RJ, Young DB: The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Mol Microbiol. 2005 Feb;55 (4) :1127-37., URL: http://www.ncbi.nlm.nih.gov/pubmed/15686559, , *Wilkinson KA, Stewart GR, Newton SM, Vordermeier HM, Wain JR, Murphy HN, Horner K, Young DB, Wilkinson RJ: Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2. J Immunol. 2005 Apr 1;174 (7) :4237-43., URL: http://www.ncbi.nlm.nih.gov/pubmed/15778386, , *Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280 (39) :33419-25., URL: https://pubmed.ncbi.nlm.nih.gov/16046399/
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
The rabbit polyclonal antibody to Acr2 reacts with Mycobacterium tuberculosis protein Acr2 (Rv0251c, Hsp20) .
Isotype
Rabbit polyclonal
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