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Anti-Acr2 (M. tuberculosis) Purified

The Mycobacterium tuberculosis antigen Acr2 (alpha-crystallin-related protein 2), also known as HrpA or Hsp20, is a small heat shock protein, which forms oligomeric assemblies. Expression of Acr2 is induced by heat shock, oxidative stress, and uptake by macrophages. It evokes a vigorous early immune response.

Product Specifications

Certification

RUO

Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Acr2 protein (produced in E. coli)

Target Antigen

Acr2 (M. tuberculosis)

Clone

PAb (188)

Applications

WB, ELISA

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Stewart GR, Newton SM, Wilkinson KA, Humphreys IR, Murphy HN, Robertson BD, Wilkinson RJ, Young DB: The stress-responsive chaperone alpha-crystallin 2 is required for pathogenesis of Mycobacterium tuberculosis. Mol Microbiol. 2005 Feb;55 (4) :1127-37., URL: http://www.ncbi.nlm.nih.gov/pubmed/15686559, , *Wilkinson KA, Stewart GR, Newton SM, Vordermeier HM, Wain JR, Murphy HN, Horner K, Young DB, Wilkinson RJ: Infection biology of a novel alpha-crystallin of Mycobacterium tuberculosis: Acr2. J Immunol. 2005 Apr 1;174 (7) :4237-43., URL: http://www.ncbi.nlm.nih.gov/pubmed/15778386, , *Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280 (39) :33419-25., URL: https://pubmed.ncbi.nlm.nih.gov/16046399/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The rabbit polyclonal antibody to Acr2 reacts with Mycobacterium tuberculosis protein Acr2 (Rv0251c, Hsp20) .

Isotype

Rabbit polyclonal

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