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Anti-Tb10.4 (M. tuberculosis) Purified

The Mycobacterium tuberculosis antigen Tb10.4, also known as EsxH, Rv0288, ESAT-6 like protein EsxH, or Cfp7, is a conserved bacterial protein which effectively induces immune response to M. tuberculosis infection. It is a promissing vaccination tool.

Product Specifications

Certification

RUO

Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Tb10.4 protein produced in E. coli

Target Antigen

Tb10.4 (M. tuberculosis)

Clone

PAb (186)

Applications

WB, ELISA

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Billeskov R, Vingsbo-Lundberg C, Andersen P, Dietrich J: Induction of CD8 T cells against a novel epitope in TB10.4: correlation with mycobacterial virulence and the presence of a functional region of difference-1. J Immunol. 2007 Sep 15;179 (6) :3973-81., URL: http://www.ncbi.nlm.nih.gov/pubmed/17785835, , *Skjø t RL, Brock I, Arend SM, Munk ME, Theisen M, Ottenhoff TH, Andersen P: Epitope mapping of the immunodominant antigen TB10.4 and the two homologous proteins TB10.3 and TB12.9, which constitute a subfamily of the esat-6 gene family. Infect Immun. 2002 Oct;70 (10) :5446-53., URL: https://pubmed.ncbi.nlm.nih.gov/12228269/, *Skjø t RL, Oettinger T, Rosenkrands I, Ravn P, Brock I, Jacobsen S, Andersen P: Comparative evaluation of low-molecular-mass proteins from Mycobacterium tuberculosis identifies members of the ESAT-6 family as immunodominant T-cell antigens. Infect Immun. 2000 Jan;68 (1) :214-20., URL: https://pubmed.ncbi.nlm.nih.gov/10603390/, *Dietrich J, Aagaard C, Leah R, Olsen AW, Stryhn A, Doherty TM, Andersen P: Exchanging ESAT6 with TB10.4 in an Ag85B fusion molecule-based tuberculosis subunit vaccine: efficient protection and ESAT6-based sensitive monitoring of vaccine efficacy. J Immunol. 2005 May 15;174 (10) :6332-9., URL: https://pubmed.ncbi.nlm.nih.gov/15879133/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The rabbit polyclonal antibody to Tb10.4 reacts with Mycobacterium tuberculosis protein Tb10.4 (EsxH) .

Isotype

Rabbit polyclonal

Frequently Asked Questions

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