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Anti-Acr1 (M. tuberculosis) Purified

The Mycobacterium tuberculosis antigen Acr1 (alpha-crystallin-related protein 1), also known as Hsp16.3, is a small heat shock protein (16 kDa), which forms oligomeric assemblies. Expression of Acr1 is induced by exposure to hypoxia or nitric oxide and is associated with bacterial persistence in a non-replicating state.

Product Specifications

Certification

RUO

Reactivity

Mycobacterium tuberculosis

Immunogen

Recombinant Acr1 protein (produced in E. coli)

Target Antigen

Acr1 (M. tuberculosis)

Clone

PAb (185)

Applications

WB, ELISA

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Other References

*Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Tadokera R, Conesa-Botella A, Seldon R, Rangaka MX, Rebe K, Pepper DJ, Morroni C, Colebunders R, Maartens G, Wilkinson RJ: Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome. Am J Respir Crit Care Med. 2012 Aug 15;186 (4) :369-77, URL: http://www.ncbi.nlm.nih.gov/pubmed/22700860, , *Kennaway CK, Benesch JL, Gohlke U, Wang L, Robinson CV, Orlova EV, Saibil HR, Keep NH: Dodecameric structure of the small heat shock protein Acr1 from Mycobacterium tuberculosis. J Biol Chem. 2005 Sep 30;280 (39) :33419-25., URL: https://pubmed.ncbi.nlm.nih.gov/16046399/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The rabbit polyclonal antibody to Acr1 reacts with Mycobacterium tuberculosis protein Acr1 (Rv2031c, Hsp16.3) .

Isotype

Rabbit polyclonal

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