Anti-Hu CD49d Purified
CD49d / integrin alpha 4, unlike other alpha integrins, neither contains an I-domain, nor undergoes disulfide-linked cleavage. It associates with beta 7 chain to form alpha 4 / beta 7 integrin, and with beta 1 chain (CD29) to form VLA-4 integrin. These complexes are important for lymphocyte migration from circulation into tissue (binding VCAM-1) and homing of T cell subsets to Peyer´s patches (binding MadCAM-1), but VLA-4 is also target for invasive bacteria which contain invasin. CD49d is essential for differentiation and migration of hematopoietic stem cells by their adhesion to bone marrow stromal cells, and provides a costimulatory signal to TCR-CD3 complex by inducing phosphorylation of some focal adhesion proteins.
Product Specifications
Certification
RUO
Target Antigen
CD49d
Clone
9F10
Applications
FC (QC tested), IHC-F
Concentration
1 mg/mL
Format
Purified
Buffer
Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
References & Citations
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Applications Notes
Immunohistochemistry: Recommended dilution: 5-10 μg/ml.
Species
Sheep, Cat, Horse, Dog, Cow, Non-human primates, Human
CAS Number
9007-83-4
Isotype
Mouse IgG1 kappa
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items