Anti-Ikaros Purified

*López-Nieva P, Santos J, Fernández-Piqueras J: Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas. Carcinogenesis. 2004 Jul;25 (7) :1299-304. , URL: http://www.ncbi.nlm.nih.gov/pubmed/14976135 , *Loeper S, Asa SL, Ezzat S: Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. Cancer Res. 2008 May 15;68 (10) :3715-23., URL: http://www.ncbi.nlm.nih.gov/pubmed/18483254 , *Kathrein KL, Lorenz R, Innes AM, Griffiths E, Winandy S: Ikaros induces quiescence and T-cell differentiation in a leukemia cell line. Mol Cell Biol. 2005 Mar;25 (5) :1645-54., URL: https://pubmed.ncbi.nlm.nih.gov/15713624/, *Schwickert TA, Tagoh H, Gültekin S, Dakic A, Axelsson E, Minnich M, Ebert A, Werner B, Roth M, Cimmino L, Dickins RA, Zuber J, Jaritz M, Busslinger M: Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol. 2014 Mar;15 (3) :283-93., URL: http://www.ncbi.nlm.nih.gov/pubmed/24509509 , *Elliott J, Jolicoeur C, Ramamurthy V, Cayouette M: Ikaros confers early temporal competence to mouse retinal progenitor cells. Neuron. 2008 Oct 9;60 (1) :26-39., URL: http://www.ncbi.nlm.nih.gov/pubmed/18940586 , *Koipally J, Heller EJ, Seavitt JR, Georgopoulos K: Unconventional potentiation of gene expression by Ikaros. J Biol Chem. 2002 Apr 12;277 (15) :13007-15., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=koipally+j+heller+ej

The mouse monoclonal antibody 4E9 recognizes Ikaros, a transcription factor (intracellular antigen) expressed broadly in hematopoietic progenitors and serving as a key regulator of lymphopoiesis.