What is the catalog number for Anti-Ikaros Purified?

The catalog number for Anti-Ikaros Purified is 11-159-C100.

What sizes are available for Anti-Ikaros Purified?

Anti-Ikaros Purified is available in the following size(s): 0.1 mg.

Is Anti-Ikaros Purified in stock?

Anti-Ikaros Purified is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Anti-Ikaros Purified?

Anti-Ikaros Purified is manufactured by AFG-XBO.

What is the estimated delivery time for Anti-Ikaros Purified?

Estimated delivery time for Anti-Ikaros Purified is approximately 10 business day(s), depending on your location.

Anti-Ikaros Purified

Ikaros, also known as IKZF1 (Ikaros family zinc finger protein 1) is a hematopoietic-specific transcription factor involved in the regulation of lymphocyte development, together with other members of this family, such as Aiolos and Helios. Ikaros forms homo- and heterodimers with these proteins and functions predominantly in early hematopoietic development. Expression of Ikaros, Aiolos and Helios is restricted to cells of the hematopoietic system, whereas other family members, Eos and Pegassus, are more widely expressed. Disruption of Ikaros leads to T and B cell leukemias.

Product Specifications

Certification

RUO

Reactivity

Mouse, Human

Immunogen

Recombinant human Ikaros (C-terminal part)

Target Antigen

Ikaros

Clone

4E9

Applications

FC (QC tested), IP, WB, ICC

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*López-Nieva P, Santos J, Fernández-Piqueras J: Defective expression of Notch1 and Notch2 in connection to alterations of c-Myc and Ikaros in gamma-radiation-induced mouse thymic lymphomas. Carcinogenesis. 2004 Jul;25 (7) :1299-304. , URL: http://www.ncbi.nlm.nih.gov/pubmed/14976135 , *Loeper S, Asa SL, Ezzat S: Ikaros modulates cholesterol uptake: a link between tumor suppression and differentiation. Cancer Res. 2008 May 15;68 (10) :3715-23., URL: http://www.ncbi.nlm.nih.gov/pubmed/18483254 , *Kathrein KL, Lorenz R, Innes AM, Griffiths E, Winandy S: Ikaros induces quiescence and T-cell differentiation in a leukemia cell line. Mol Cell Biol. 2005 Mar;25 (5) :1645-54., URL: https://pubmed.ncbi.nlm.nih.gov/15713624/, *Schwickert TA, Tagoh H, Gültekin S, Dakic A, Axelsson E, Minnich M, Ebert A, Werner B, Roth M, Cimmino L, Dickins RA, Zuber J, Jaritz M, Busslinger M: Stage-specific control of early B cell development by the transcription factor Ikaros. Nat Immunol. 2014 Mar;15 (3) :283-93., URL: http://www.ncbi.nlm.nih.gov/pubmed/24509509 , *Elliott J, Jolicoeur C, Ramamurthy V, Cayouette M: Ikaros confers early temporal competence to mouse retinal progenitor cells. Neuron. 2008 Oct 9;60 (1) :26-39., URL: http://www.ncbi.nlm.nih.gov/pubmed/18940586 , *Koipally J, Heller EJ, Seavitt JR, Georgopoulos K: Unconventional potentiation of gene expression by Ikaros. J Biol Chem. 2002 Apr 12;277 (15) :13007-15., URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=koipally+j+heller+ej

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody 4E9 recognizes Ikaros, a transcription factor (intracellular antigen) expressed broadly in hematopoietic progenitors and serving as a key regulator of lymphopoiesis.