Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Hu IgD Purified

Immunoglobulin D (IgD) is expressed on the surface of naive mature B cells, thus later than IgM, and is coexpressed with it then. Triggered by antigen binding, it signals through the CD79 complex to activate the B cells. Expression of IgD is lost after the isotype switch. Soluble IgD is present in very small amounts in the serum. IgD can bind to basophils and mast cells to activate them in an IgE-independent way to participate in respiratory immune defense.

Product Specifications

Certification

RUO

Reactivity

Human

Immunogen

Human IgD

Target Antigen

IgD

Clone

IA6-2

Applications

FC (QC tested), IHC-F

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Bunch DO, McGregor JG, Khandoobhai NB, Aybar LT, Burkart ME, Hu Y, Hogan SL, Poulton CJ, Berg EA, Falk RJ, Nachman PH: Decreased CD5⁺ B cells in active ANCA vasculitis and relapse after rituximab. Clin J Am Soc Nephrol. 2013 Mar;8 (3) :382-91, URL: https://pubmed.ncbi.nlm.nih.gov/23293123/, *Baier G, Baier-Bitterlich G, Looney DJ, Altman A: Immunogenic targeting of recombinant peptide vaccines to human antigen-presenting cells by chimeric anti-HLA-DR and anti-surface immunoglobulin D antibody Fab fragments in vitro. J Virol. 1995 Apr;69 (4) :2357-65., URL: https://pubmed.ncbi.nlm.nih.gov/7533857/, *Ferrari S, Giliani S, Insalaco A, Al-Ghonaium A, Soresina AR, Loubser M, Avanzini MA, Marconi M, Badolato R, Ugazio AG, Levy Y, Catalan N, Durandy A, Tbakhi A, Notarangelo LD, Plebani A: Mutations of CD40 gene cause an autosomal recessive form of immunodeficiency with hyper IgM. Proc Natl Acad Sci U S A. 2001 Oct 23;98 (22) :12614-9., URL: https://www.ncbi.nlm.nih.gov/pubmed/11675497, *Di Sabatino A, Carsetti R, Rosado MM, Ciccocioppo R, Cazzola P, Morera R, Tinozzi FP, Tinozzi S, Corazza GR: Immunoglobulin M memory B cell decrease in inflammatory bowel disease. Eur Rev Med Pharmacol Sci. 2004 Sep-Oct;8 (5) :199-203., URL: https://pubmed.ncbi.nlm.nih.gov/15638230/, *Pugh-Bernard AE, Silverman GJ, Cappione AJ, Villano ME, Ryan DH, Insel RA, Sanz I: Regulation of inherently autoreactive VH4-34 B cells in the maintenance of human B cell tolerance. J Clin Invest. 2001 Oct;108 (7) :1061-70., URL: https://pubmed.ncbi.nlm.nih.gov/11581307/, *Degauque N, Ngono AE, Akl A, Lepetit M, Crochette R, Giral M, Lepourry J, Pallier A, Castagnet S, Dugast E, Guillot-Gueguen C, Jacq-Foucher M, Saulquin X, Cesbron A, Laplaud D, Nicot A, Brouard S, Soulillou JP: Characterization of antigen-specific B cells using nominal antigen-coated flow-beads. PLoS One. 2013 Dec 30;8 (12) :e84273., URL: https://pubmed.ncbi.nlm.nih.gov/24386360/, *Chang NH, McKenzie T, Bonventi G, Landolt-Marticorena C, Fortin PR, Gladman D, Urowitz M, Wither JE: Expanded population of activated antigen-engaged cells within the naive B cell compartment of patients with systemic lupus erythematosus. J Immunol. 2008 Jan 15;180 (2) :1276-84., URL: http://www.ncbi.nlm.nih.gov/pubmed/18178868 , *Quardokus EM, Saunders DC, McDonough E, Hickey JW, Werlein C, Surrette C, Rajbhandari P, Martinez Casals A, Tian H, Lowery L, Neumann EK, Björklund F, Neelakantan TV, Croteau J, Wiblin AE, Fisher J, Livengood AJ, Dowell KG, Silverstein JC, Spraggins JM, Pryhuber GS, Deutsch G, Ginty F, Nolan GP, Melov S, Jonigk D, Caldwell MA, Vlachos IS, Mueller W, Gehlenborg N, Stockwell BR, Lundberg E, Snyder MP, Germain RN, Camarillo JM, Kelleher NL, Börner K, Radtke AJ: Organ mapping antibody panels: a community resource for standardized multiplexed tissue imaging. Nat Methods 2023 Aug;20 (8) :1174-1178. doi: 10.1038/s41592-023-01846-7., URL: https://pubmed.ncbi.nlm.nih.gov/37468619/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody IA6-2 recognizes human immunoglobulin D.

Applications Notes

Flow cytometry: Recommended dilution: 2-4 μg/ml.

Isotype

Mouse IgG2a kappa

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Angptl7 siRNA Oligos set (Mouse)
11903174 3x 5 nmol

Angptl7 siRNA Oligos set (Mouse)

Sign In for Pricing
View Details
Ethyl 4-iodo-1- (4-methoxybenzyl) -1H-pyrazole-3-carboxylate
OR1056705-01 100 mg

Ethyl 4-iodo-1- (4-methoxybenzyl) -1H-pyrazole-3-carboxylate

Sign In for Pricing
View Details
Ethyl 4-iodo-1- (4-methoxybenzyl) -1H-pyrazole-3-carboxylate
OR1056705-02 250 mg

Ethyl 4-iodo-1- (4-methoxybenzyl) -1H-pyrazole-3-carboxylate

Sign In for Pricing
View Details
Ethyl 4-iodo-1- (4-methoxybenzyl) -1H-pyrazole-3-carboxylate
OR1056705-03 1 g

Ethyl 4-iodo-1- (4-methoxybenzyl) -1H-pyrazole-3-carboxylate

Sign In for Pricing
View Details
mmu-miR-99b-3p miRNA Mimic
MBS8301007-01 5 nmol

mmu-miR-99b-3p miRNA Mimic

Sign In for Pricing
View Details
mmu-miR-99b-3p miRNA Mimic
MBS8301007-02 10 nmol

mmu-miR-99b-3p miRNA Mimic

Sign In for Pricing
View Details