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Anti-Hu CD11b Purified Azide Free

CD11b (integrin alphaM subunit) is a 165-170 kDa type I transmembrane glycoprotein that non-covalently associates with integrin beta2 subunit (CD18) ; expression of the CD11b chain on the cell surface requires the presence of the CD18 antigen. CD11b/CD18 integrin (Mac-1, CR3) is highly expressed on NK cells, neutrophils, monocytes and less on macrophages. CD11b/CD18 integrin is implicated in various adhesive interactions of monocytes, macrophages and granulocytes, facilitating their diapedesis, as well as it mediates the uptake of complement coated particles, serving as a receptor for the iC3b fragment of the third complement component.

Product Specifications

Certification

RUO

Immunogen

Human granulocytes

Target Antigen

CD11b

Clone

MEM-170

Applications

FC (QC tested), FUNC

Concentration

1 mg/mL

Format

Purified Azide Free

Buffer

Phosphate buffered saline (PBS), pH 7.4

References & Citations

*Machacek C, Supper V, Leksa V, Mitulovic G, Spittler A, Drbal K, Suchanek M, Ohradanova-Repic A, Stockinger H: Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen. J Immunol. 2016 Sep 15;197 (6) :2229-38., URL: https://www.ncbi.nlm.nih.gov/pubmed/27534550

Other References

*Hentzen ER, Neelamegham S, Kansas GS, Benanti JA, McIntire LV, Smith CW, Simon SI. Sequential binding of CD11a/CD18 and CD11b/CD18 defines neutrophil capture and stable adhesion to intercellular adhesion molecule-1. Blood. 2000 Feb 1;95 (3) :911-20., URL: https://pubmed.ncbi.nlm.nih.gov/10648403/, *Lawrence PK, Srikumaran S: CD11b of Ovis canadensis and Ovis aries: molecular cloning and characterization. Vet Immunol Immunopathol. 2007 Oct 15;119 (3-4) :287-98., URL: https://pubmed.ncbi.nlm.nih.gov/17628696/, *Akramiene D, Kondrotas A, Didziapetriene J, Kevelaitis E: Effects of beta-glucans on the immune system. Medicina (Kaunas) . 2007;43 (8) :597-606., URL: https://pubmed.ncbi.nlm.nih.gov/17895634/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The antibody MEM-170 recognizes an extracellular epitope of CD11b antigen (Mac-1alpha), a 165-170 kDa transmembrane protein type 1 mainly expressed on monocytes, granulocytes and NK-cells. The antibody blocks (not completely) Mac-1-mediated neutrophil binding to fibrinogen.

Species

Human

CAS Number

9007-83-4

Isotype

Mouse IgG1

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