Anti-Hu CD40 Purified Azide Free
CD40 is a costimulatory molecule of the TNF receptor superfamily and is expressed on many cell types, such as B cells, monocytes/macrophages, dendritic cells, endothelial cells, fibroblasts or vascular smooth muscle cells. Interaction of CD40 and its ligand CD154 (CD40L) is required for the generation of antibody responses to T-dependent antigens as well as for the development of germinal centers and memory B cells. In monocytes/macrophages CD40 engagement induces production of pro-inflammatory cytokines and chemokines. CD40-CD154 interactions are also critical for development of CD4 T cell-dependent effector functions. CD40 links innate and adaptive immune responses to bacterial stimuli and serves as an important regulator affecting functions of other costimulatory molecules.
Product Specifications
Certification
RUO
Immunogen
Human CD40a
Target Antigen
CD40
Clone
HI40a
Applications
FC (QC tested)
Concentration
1 mg/mL
Format
Purified Azide Free
Buffer
Phosphate buffered saline (PBS), pH 7.4
References & Citations
Other References
Storage Conditions
Store at 2-8°C. Do not freeze.
Specificity
Applications Notes
Flow cytometry: The purified antibody is effective for indirect immunofluorescence staining of human cells by flow cytometry analysis using 1 μg/ml.
Species
Human
CAS Number
9007-83-4
Isotype
Mouse IgG1
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