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Lipoamide

Lipoamide ((±) -α-Lipoamide) is a monocarboxylic acid derivative of a neutral amide, formed by the condensation of the carboxyl group of lipoic acid and ammonia. Lipoamide protects against oxidative stress-mediated neuronal cell damage and also acts as a coenzyme to transfer acetyl groups and hydrogen during pyruvate deacylation. Lipoamide also stimulates mitochondrial biogenesis in adipocytes through the endothelial NO synthase-cGMP-protein kinase G signaling pathway[1][2].

Product Specifications

CAS Number

[940-69-2]

Product Name Alternative

(±) -α-Lipoamide; DL-Lipoamide; DL-6,8-Thioctamide

UNSPSC

12352005

Hazard Statement

H302

Target

NO Synthase

Type

Natural Products

Related Pathways

Immunology/Inflammation

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/Lipoamide.html

Purity

99.58

Solubility

DMSO : ≥ 50 mg/mL

Smiles

O=C(N)CCCCC1SSCC1

Molecular Formula

C8H15NOS2

Molecular Weight

205.34

Precautions

H302

References & Citations

[1]E S Arnér, et al. Efficient reduction of lipoamide and lipoic acid by mammalian thioredoxin reductase. Biochem Biophys Res Commun. 1996 Aug 5;225 (1) :268-74.|[2]Hou Y, et al. Lipoamide Ameliorates Oxidative Stress via Induction of Nrf2/ARE Signaling Pathway in PC12 Cells. J Agric Food Chem. 2019 Jul 24;67 (29) :8227-8234.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Natural Products

Clinical Information

No Development Reported

Isoform

Human Endogenous Metabolite

Available Sizes

Curated Selection

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