CHF-6550
CHF-6550 is an antagonist for muscarinic M3 receptor and an agonist for β2 adrenoceptor (MABA), with pKi of 9.3 and 10.6, respectively. CHF-6550 exhibits good hepatocyte clearance in rat models and good pharmacokinetic characteristics in guinea pigs[1].
Product Specifications
CAS Number
3052116-62-5
UNSPSC
12352005
Target
Adrenergic Receptor; mAChR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/chf-6550.html
Smiles
O=C(C1=CC=C(C=C1)CNC[C@H](O)C2=C3C=CC(NC3=C(C=C2)O)=O)NCCCOC4=CC=CC([C@](O)(C(O[C@H]5CN(CCC5)C)=O)C6=CC=CC=C6)=C4
Molecular Formula
C42H46N4O8
Molecular Weight
734.84
References & Citations
[1]Carzaniga L, et al., Discovery, Multiparametric Optimization, and Solid-State Driven Identification of CHF-6550, a Novel Soft Dual Pharmacology Muscarinic Antagonist and β2 Agonist (MABA) for the Inhaled Treatment of Respiratory Diseases. J Med Chem. 2024 Jun 10.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MAChR3; β adrenergic receptor
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