FAK (Phospho Ser722) rabbit pAb

Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Domain: The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions. Domain: The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL. function: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. PTM: Phosphorylated on 6 tyrosine residues upon activation. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. similarity: Contains 1 FERM domain. similarity: Contains 1 protein kinase domain. subcellular location: Constituent of focal adhesions. subunit: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with RGNEF and SHB (By similarity). Interacts with TGFB1I1. tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.