IRAK inhibitor 1

IRAK inhibitor 1 is a potent IRAK-4 inhibitor with IC50 of 216 nM, is poorly active against JNK-1 and JNK-2 with IC50 of 3.801 μM, and >10 μM, respectively.

Product Specifications

CAS Number

[1042224-63-4]

UNSPSC

12352005

Hazard Statement

H301+H311, H311, H331

Target

IRAK

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/IRAK-inhibitor-1.html

Purity

99.83

Solubility

DMSO : 16.67 mg/mL (ultrasonic)

Smiles

C1(C2=CN=C3N2C=CC=C3)=CC=CC(NC4CCNCC4)=N1

Molecular Formula

C17H19N5

Molecular Weight

293.37

Precautions

H301+H311, H311, H331

References & Citations

[1]Buckley GM, et al. IRAK-4 inhibitors. Part II: A structure-based assessment of imidazo[1,2-a]pyridine binding. Bioorg Med Chem Lett. 2008 Jun 1;18 (11) :3291-5.|[2]Li S, et al. IRAK-4: a novel member of the IRAK family with the properties of an IRAK-kinase. Proc Natl Acad Sci U S A. 2002 Apr 16;99 (8) :5567-72.